Tariq Yousuf1, Taylor Brinton1, Jason Kramer2, Basharath Khan1, Jeffrey Ziffra1, Dana Villines3, Poorvi Shah4, Tabassum Hanif5. 1. Department of Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL. 2. Rosalind Franklin University of Medicine and Science, Chicago, IL. 3. Department of Research, Advocate Christ Medical Center, Oak Lawn, IL. 4. Department of Pharmacy, Advocate Christ Medical Center, Oak Lawn, IL. 5. Department of Pulmonary/Critical Care Medicine, Advocate Christ Medical Center, Oak Lawn, IL.
Abstract
BACKGROUND: Respiratory depression is a common adverse effect of benzodiazepine administration to patients with severe alcoholic withdrawal. This study was conducted to assess the value of end tidal carbon dioxide (ETCO2) levels compared to partial pressure of arterial carbon dioxide (PaCO2) levels in monitoring respiratory depression secondary to benzodiazepine treatment in patients with severe alcohol withdrawal. METHODS: We retrospectively analyzed 36 patients admitted to the intensive care unit for severe alcohol withdrawal who had been administered sedative agents. RESULTS: We observed a statistically significant correlation between PaCO2 and ETCO2 at time 1 (r=0.74, P<0.01) and time 3 (r=0.52, P=0.02) but not at time 2 (r=0.22, P=0.31). CONCLUSION: Our study confirms a positive correlation between PaCO2 and ETCO2 levels in patients experiencing severe alcohol withdrawal.
BACKGROUND:Respiratory depression is a common adverse effect of benzodiazepine administration to patients with severe alcoholic withdrawal. This study was conducted to assess the value of end tidal carbon dioxide (ETCO2) levels compared to partial pressure of arterial carbon dioxide (PaCO2) levels in monitoring respiratory depression secondary to benzodiazepine treatment in patients with severe alcohol withdrawal. METHODS: We retrospectively analyzed 36 patients admitted to the intensive care unit for severe alcohol withdrawal who had been administered sedative agents. RESULTS: We observed a statistically significant correlation between PaCO2 and ETCO2 at time 1 (r=0.74, P<0.01) and time 3 (r=0.52, P=0.02) but not at time 2 (r=0.22, P=0.31). CONCLUSION: Our study confirms a positive correlation between PaCO2 and ETCO2 levels in patients experiencing severe alcohol withdrawal.
Entities:
Keywords:
Alcohol withdrawal delirium; blood gas analysis; capnography; respiratory insufficiency
Authors: Jonathan Rosenson; Carter Clements; Barry Simon; Jules Vieaux; Sarah Graffman; Farnaz Vahidnia; Bitou Cisse; Joseph Lam; Harrison Alter Journal: J Emerg Med Date: 2012-09-19 Impact factor: 1.484