The Effects of Hydrophilic Polyethylene Glycol-Based Adhesion Barrier Use to Prevent Intra-abdominal Adhesions in Intra-abdominal Sepsis Model.

Postoperative adhesion formation is still an important cause of morbidity and mortality. Hydrophilic polyethylene glycol-based adhesion barrier (SprayGel™, Confluent Surgical, Inc., Waltham, MA) is reported to prevent adhesion formation after gynecologic surgery. This study aims to determine the effectiveness of SprayGel™ on adhesion formation after laparotomy in an experimental septic peritonitis model. Wistar albino male rats with weights of 250-350 g were used in this study. Forty rats were grouped into four groups: group I (control), laparotomy and sham operation; group II, laparotomy and cecal ligation puncture (CLP); group III (SprayGel™), laparotomy, sham operation, and SprayGel™; group IV (CLP + SprayGel™), laparotomy, CLP, and SprayGel™. Intra-abdominal sepsis was achieved by perforating the cecum with a 26-gauge needle in selected groups. All animals were sacrificed after 10 days. The results were evaluated according to the score systems of Nair and Knightly. Kruskal-Wallis variance analysis was used for statistical analysis. There were significant differences for the development of adhesion between groups II (CLP) and III-IV (SprayGel™ - CLP + SprayGel™) (p < 0.02). Mortality and wound infection rates were significantly lower in the SprayGel™ treatment groups compared to control groups. Intraperitoneal administration of SprayGel™ significantly decreased the intraperitoneal adhesion formation, and it reduced mortality and wound infection as well.