Literature DB >> 26729836

Alzheimer's disease: the amyloid hypothesis on trial.

Judith R Harrison1, Michael J Owen2.   

Abstract

The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis. © The Royal College of Psychiatrists 2016.

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Year:  2016        PMID： 26729836     DOI： 10.1192/bjp.bp.115.167569

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  22 in total

Review 1.  Understanding mechanisms and seeking cures for Alzheimer's disease: why we must be "extraordinarily diverse".

Authors:  Madhav Thambisetty
Journal:  Am J Physiol Cell Physiol       Date:  2017-06-14       Impact factor: 4.249

2.  PET imaging of tau protein targets: a methodology perspective.

Authors:  Cristina Lois; Ivan Gonzalez; Keith A Johnson; Julie C Price
Journal:  Brain Imaging Behav       Date:  2019-04       Impact factor: 3.978

3.  Evidence of demyelination in mild cognitive impairment and dementia using a direct and specific magnetic resonance imaging measure of myelin content.

Authors:  Mustapha Bouhrara; David A Reiter; Christopher M Bergeron; Linda M Zukley; Luigi Ferrucci; Susan M Resnick; Richard G Spencer
Journal:  Alzheimers Dement       Date:  2018-04-19       Impact factor: 21.566

4.  Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway.

Authors:  Jiao Meng; Yuhua Chen; Fangfang Bi; Hua Li; Cuicui Chang; Wei Liu
Journal:  Am J Transl Res       Date:  2019-10-15       Impact factor: 4.060

5.  Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer's Disease Phenotype in iPSC Derived Human Neurons.

Authors:  Bonnie J Berry; Alec S T Smith; Christopher J Long; Candace C Martin; James J Hickman
Journal:  ACS Chem Neurosci       Date:  2018-05-22       Impact factor: 4.418

6.  Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles.

Authors:  Kai-C Sonntag; Woo-In Ryu; Kristopher M Amirault; Ryan A Healy; Arthur J Siegel; Donna L McPhie; Brent Forester; Bruce M Cohen
Journal:  Sci Rep       Date:  2017-10-25       Impact factor: 4.379

Review 7.  Half a century of amyloids: past, present and future.

Authors:  Pu Chun Ke; Ruhong Zhou; Louise C Serpell; Roland Riek; Tuomas P J Knowles; Hilal A Lashuel; Ehud Gazit; Ian W Hamley; Thomas P Davis; Marcus Fändrich; Daniel Erik Otzen; Matthew R Chapman; Christopher M Dobson; David S Eisenberg; Raffaele Mezzenga
Journal:  Chem Soc Rev       Date:  2020-07-07       Impact factor: 54.564

Review 8.  Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer's disease.

Authors:  David L Brody; Hao Jiang; Norelle Wildburger; Thomas J Esparza
Journal:  Alzheimers Res Ther       Date:  2017-08-17       Impact factor: 6.982

Review 9.  The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology.

Authors:  Nadia Canu; Giuseppina Amadoro; Viviana Triaca; Valentina Latina; Valentina Sposato; Veronica Corsetti; Cinzia Severini; Maria Teresa Ciotti; Pietro Calissano
Journal:  Int J Mol Sci       Date:  2017-06-20       Impact factor: 5.923

10.  RGS2 expression predicts amyloid-β sensitivity, MCI and Alzheimer's disease: genome-wide transcriptomic profiling and bioinformatics data mining.

Authors:  A Hadar; E Milanesi; A Squassina; P Niola; C Chillotti; M Pasmanik-Chor; O Yaron; P Martásek; M Rehavi; D Weissglas-Volkov; N Shomron; I Gozes; D Gurwitz
Journal:  Transl Psychiatry       Date:  2016-10-04       Impact factor: 6.222
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