Marijana Tadic1, Cesare Cuspidi2, Sanja Ilic3, Tamara Marjanovic1, Vera Celic1,4, Sladjana Trpkovic5. 1. a Department of Cardiology , University Clinical Hospital Centre "Dr. Dragisa Misovic - Dedinje" , Belgrade , Serbia ; 2. b Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano , Meda , Italy ; 3. c Department of Endocrinology , University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje" , Belgrade , Serbia ; 4. d Faculty of Medicine , Belgrade , Serbia ; 5. e Clinical Center Pristina, Gracanica, Medical Faculty Pristina, Kosovska Mitrovica, Clinic for General Surgery , Kosovska Mitrovica , Serbia.
Abstract
BACKGROUND: We sought to evaluate left atrial (LA) and right atrial (RA) phasic function and deformation in the subclinical hyperthyroidism (SCH) using two- and three-echocardiographic (2DE and 3DE) methods. METHODS: We included 45 untreated women with SCH and 45 healthy women who underwent comprehensive 2DE and 3DE examination. RESULTS: Total and passive LA emptying fractions (EF) were decreased, whereas active EF was increased among the SCH participants. RA total EFs were similar between the controls and the SCH subjects; passive EF was reduced; and active EF was amplified in the SCH group. TSH correlated with 2DE LA passive and active EFs, 3DE LA total, passive and active EFs, as well as 2DE LA positive longitudinal strain. Additionally, TSH correlated with 2DE RA passive and active EFs, 3DE LA and RA passive EF, 2DE LA and RA positive longitudinal strain. However, after adjustment for the parameters of left and right ventricular diastolic function and structure, the TSH level remained associated only with LA conduit and booster pump functions, as well as RA pump function. CONCLUSION: Biatrial phasic function evaluated by 2DE and 3DE is significantly impaired in the SCH subjects. TSH level correlates with LA and RA conduit and pump functions.
BACKGROUND: We sought to evaluate left atrial (LA) and right atrial (RA) phasic function and deformation in the subclinical hyperthyroidism (SCH) using two- and three-echocardiographic (2DE and 3DE) methods. METHODS: We included 45 untreated women with SCH and 45 healthy women who underwent comprehensive 2DE and 3DE examination. RESULTS: Total and passive LA emptying fractions (EF) were decreased, whereas active EF was increased among the SCHparticipants. RA total EFs were similar between the controls and the SCH subjects; passive EF was reduced; and active EF was amplified in the SCH group. TSH correlated with 2DE LA passive and active EFs, 3DE LA total, passive and active EFs, as well as 2DE LA positive longitudinal strain. Additionally, TSH correlated with 2DERA passive and active EFs, 3DE LA and RA passive EF, 2DE LA and RA positive longitudinal strain. However, after adjustment for the parameters of left and right ventricular diastolic function and structure, the TSH level remained associated only with LA conduit and booster pump functions, as well as RA pump function. CONCLUSION: Biatrial phasic function evaluated by 2DE and 3DE is significantly impaired in the SCH subjects. TSH level correlates with LA and RA conduit and pump functions.
Entities:
Keywords:
Left atrium; phasic function; right atrium; subclinical hyperthyroidism; three-dimensional echocardiography; two-dimensional speckle tracking
Authors: Rodrigo A Peliciari-Garcia; Paula Bargi-Souza; Martin E Young; Maria Tereza Nunes Journal: Chronobiol Int Date: 2017-11-07 Impact factor: 2.877