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Literature DB >> 2672824

Granulocyte chemotactic protein/interleukin-8 induces plasma leakage and neutrophil accumulation in rabbit skin.

M Rampart¹, J Van Damme, L Zonnekeyn, A G Herman.

Abstract

Granulocyte chemotactic protein/Interleukin-8 (GCP/IL-8), purified to homogeneity from endotoxin- or mitogen-stimulated human mononuclear cells, was injected intradermally into rabbits to evaluate the proinflammatory properties of this novel cytokine. In the presence of a vasodilator substance, pmol amounts of GCP/IL-8 induced neutrophil accumulation that was fast in onset, relatively short of duration (half life 60 to 70 minutes), and was associated with a parallel time course of plasma protein extravasation. GCP/IL-8-induced edema formation was found to be neutrophil dependent. These data provide evidence that GCP/IL-8 fulfills two important criteria for consideration as an inflammatory mediator. It is possible that endogenous GCP/IL-8, if produced locally by tissue macrophages, may contribute to the initiation of the inflammatory response to infection.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2672824 PMCID： PMC1880227

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

16 in total

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Authors: J Westwick; S W Li; R D Camp
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Journal: J Immunol Date: 1987-11-15 Impact factor: 5.422

3. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

Authors: T Yoshimura; K Matsushima; S Tanaka; E A Robinson; E Appella; J J Oppenheim; E J Leonard
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6. The in vivo effect of leukotriene B4 on polymorphonuclear leukocytes and the microcirculation. Comparison with activated complement (C5a des Arg) and enhancement by prostaglandin E2.

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Authors: P Peveri; A Walz; B Dewald; M Baggiolini
Journal: J Exp Med Date: 1988-05-01 Impact factor: 14.307

9. A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity.

Authors: J Van Damme; J Van Beeumen; G Opdenakker; A Billiau
Journal: J Exp Med Date: 1988-04-01 Impact factor: 14.307

10. Mediation of increased vascular permeability after complement activation. Histamine-independent action of rabbit C5a.

Authors: T J Williams; P J Jose
Journal: J Exp Med Date: 1981-01-01 Impact factor: 14.307

28 in total

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3. Induction of neutrophil infiltration by rat chemotactic cytokine (CINC) and its inhibition by dexamethasone in rats.

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Journal: J Biol Chem Date: 2004-12-09 Impact factor: 5.157

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Authors: H G Folkesson; M A Matthay; C A Hébert; V C Broaddus
Journal: J Clin Invest Date: 1995-07 Impact factor: 14.808

6. Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation.

Authors: L Mazzucchelli; C Hauser; K Zgraggen; H Wagner; M Hess; J A Laissue; C Mueller
Journal: Am J Pathol Date: 1994-05 Impact factor: 4.307