Literature DB >> 26728103

Short Communication: Preferential Killing of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor.

Hongmei Li1,2, Hui He3, Leyi Gong4, Mingui Fu3, Tony T Wang2.   

Abstract

We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the protein kinase C agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s). Altogether, the combination of MI-2 and bryostatin 1 displays selective killing of HIV latently infected CD4(+) T cells.

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Year:  2016        PMID： 26728103      PMCID： PMC4761853          DOI： 10.1089/AID.2015.0343

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  24 in total

1.  MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.

Authors:  Lorena Fontan; Chenghua Yang; Venkataraman Kabaleeswaran; Laurent Volpon; Michael J Osborne; Elena Beltran; Monica Garcia; Leandro Cerchietti; Rita Shaknovich; Shao Ning Yang; Fang Fang; Randy D Gascoyne; Jose Angel Martinez-Climent; J Fraser Glickman; Katherine Borden; Hao Wu; Ari Melnick
Journal:  Cancer Cell       Date:  2012-12-11       Impact factor: 31.743

2.  Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.

Authors:  Daniel Nagel; Stefani Spranger; Michelle Vincendeau; Michael Grau; Silke Raffegerst; Bernhard Kloo; Daniela Hlahla; Martin Neuenschwander; Jens Peter von Kries; Kamyar Hadian; Bernd Dörken; Peter Lenz; Georg Lenz; Dolores J Schendel; Daniel Krappmann
Journal:  Cancer Cell       Date:  2012-12-11       Impact factor: 31.743

3.  Monocyte chemotactic protein-induced protein 1 (MCPIP1) suppresses stress granule formation and determines apoptosis under stress.

Authors:  Dongfei Qi; Shengping Huang; Ruidong Miao; Zhi-Gang She; Tim Quinn; Yingzi Chang; Jianguo Liu; Daping Fan; Y Eugene Chen; Mingui Fu
Journal:  J Biol Chem       Date:  2011-10-04       Impact factor: 5.157

4.  Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation.

Authors:  Takuya Uehata; Hidenori Iwasaki; Alexis Vandenbon; Kazufumi Matsushita; Eduardo Hernandez-Cuellar; Kanako Kuniyoshi; Takashi Satoh; Takashi Mino; Yutaka Suzuki; Daron M Standley; Tohru Tsujimura; Hiromi Rakugi; Yoshitaka Isaka; Osamu Takeuchi; Shizuo Akira
Journal:  Cell       Date:  2013-05-23       Impact factor: 41.582

5.  MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells.

Authors:  Shufeng Liu; Chao Qiu; Ruidong Miao; Jianhua Zhou; Aram Lee; Baoming Liu; Sandra N Lester; Weihui Fu; Lingyan Zhu; Linxia Zhang; Jianqing Xu; Daping Fan; Kui Li; Mingui Fu; Tianyi Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-04       Impact factor: 11.205

6.  Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy.

Authors:  Anthony R Cillo; Michele D Sobolewski; Ronald J Bosch; Elizabeth Fyne; Michael Piatak; John M Coffin; John W Mellors
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-31       Impact factor: 11.205

7.  MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling.

Authors:  Jian Liang; Yasser Saad; Tianhua Lei; Jing Wang; Dongfei Qi; Qinglin Yang; Pappachan E Kolattukudy; Mingui Fu
Journal:  J Exp Med       Date:  2010-11-29       Impact factor: 14.307

8.  Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Authors:  Ya-Chi Ho; Liang Shan; Nina N Hosmane; Jeffrey Wang; Sarah B Laskey; Daniel I S Rosenbloom; Jun Lai; Joel N Blankson; Janet D Siliciano; Robert F Siliciano
Journal:  Cell       Date:  2013-10-24       Impact factor: 41.582

9.  Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase.

Authors:  Jiwei Xu; Wei Peng; Yao Sun; Xiangxi Wang; Yihui Xu; Xuemei Li; Guangxia Gao; Zihe Rao
Journal:  Nucleic Acids Res       Date:  2012-05-04       Impact factor: 16.971

10.  New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo.

Authors:  C Korin Bullen; Gregory M Laird; Christine M Durand; Janet D Siliciano; Robert F Siliciano
Journal:  Nat Med       Date:  2014-03-23       Impact factor: 53.440
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  9 in total

Review 1.  Regnase-1, a rapid response ribonuclease regulating inflammation and stress responses.

Authors:  Renfang Mao; Riyun Yang; Xia Chen; Edward W Harhaj; Xiaoying Wang; Yihui Fan
Journal:  Cell Mol Immunol       Date:  2017-02-13       Impact factor: 11.530

Review 2.  New targets for HIV drug discovery.

Authors:  Ana C Puhl; Alfredo Garzino Demo; Vadim A Makarov; Sean Ekins
Journal:  Drug Discov Today       Date:  2019-03-15       Impact factor: 7.851

Review 3.  RNA-binding proteins in immune regulation: a focus on CCCH zinc finger proteins.

Authors:  Mingui Fu; Perry J Blackshear
Journal:  Nat Rev Immunol       Date:  2016-12-19       Impact factor: 53.106

4.  Candidate host epigenetic marks predictive for HIV reservoir size, responsiveness to latency reversal, and viral rebound.

Authors:  Michael J Corley; Alina P S Pang; Thomas A Rasmussen; Martin Tolstrup; Ole S Søgaard; Lishomwa C Ndhlovu
Journal:  AIDS       Date:  2021-11-15       Impact factor: 4.177

5.  MCPIP1/regnase-I inhibits simian immunodeficiency virus and is not counteracted by Vpx.

Authors:  Hongmei Li; Tony T Wang
Journal:  J Gen Virol       Date:  2016-04-13       Impact factor: 3.891

6.  Porcine Reproductive and Respiratory Syndrome Virus Adapts Antiviral Innate Immunity via Manipulating MALT1.

Authors:  Han Gu; Suya Zheng; Guangwei Han; Haotian Yang; Zhuofan Deng; Zehui Liu; Fang He
Journal:  mBio       Date:  2022-04-25       Impact factor: 7.786

7.  Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury.

Authors:  Yong Li; Xuan Huang; Shengping Huang; Hui He; Tianhua Lei; Fatma Saaoud; Xiao-Qiang Yu; Ari Melnick; Anil Kumar; Christopher J Papasian; Daping Fan; Mingui Fu
Journal:  Signal Transduct Target Ther       Date:  2017-12-08

8.  MALT1 protease activity in primary effusion lymphoma.

Authors:  Mélanie Juilland; Luca Bonsignore; Margot Thome
Journal:  Oncotarget       Date:  2017-12-26

9.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.

Authors:  Hiroyasu Kidoya; Fumitaka Muramatsu; Teppei Shimamura; Weizhen Jia; Takashi Satoh; Yumiko Hayashi; Hisamichi Naito; Yuya Kunisaki; Fumio Arai; Masahide Seki; Yutaka Suzuki; Tsuyoshi Osawa; Shizuo Akira; Nobuyuki Takakura
Journal:  Nat Commun       Date:  2019-03-06       Impact factor: 14.919
  9 in total

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