| Literature DB >> 26727588 |
Kang He1, Chang-An Geng1, Tuan-Wu Cao1, Hong-Ling Wang1, Yun-Bao Ma1, Xue-Mei Zhang1, Ji-Jun Chen1.
Abstract
Two new secoiridoids, swerpatic acid (1) with an unusual C8 skeleton and swerpalactone (2), were isolated along with ten known compounds (3-12) from the whole plants of Swertia patens. Their structures were elucidated by comprehensive spectroscopic analyses. Eight compounds were evaluated for their anti-hepatitis B virus (HBV) activities on Hep G 2.2.15 cell line in vitro. Compounds 4 and 10 showed moderate inhibitory activities on the secretion of HBsAg with IC50 values of 1.96 and 0.50 mM.Entities:
Keywords: Swertia patens; anti-HBV activity; secoiridoids; swerpalactone; swerpatic acid
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Year: 2016 PMID： 26727588 DOI： 10.1080/10286020.2015.1116523
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569