BACKGROUND: With the increasing number of studies indicating that two single-nucleotide polymorphisms (SNPs), rs1061170 and rs1410996, in complement factor H (CFH) might be associated with the susceptibility to age-related macular degeneration (AMD), the exact association still remains uncertain. Thus, we conducted a meta-analysis to systematically summarize and clarify the association between the two SNPs and the AMD risk particularly in an Asian population. METHODS: A systematic search of studies on the association of two SNPs with the susceptibility to AMD was conducted in PubMed, Embase and Web of Science. Summary odds ratios (ORs) and 95% confidence intervals (CIs) of allele contrast and genotype contrast were estimated using the random or fixed effects model. The Q statistic test was used to identify heterogeneity, and the funnel plot was adopted to evaluate publication bias. A total of 19 case-control studies on rs1061170 and 8 studies on rs1410996 were included. RESULTS: Clearly a significantly increased trend of AMD was observed with the rs1061170 (T vs. C: OR = 1.91, 95% CI = 1.71-2.13, pH = 0.029; TC vs. CC: OR = 2.11, 95% CI = 1.30-3.42, pH = 0.792; TT vs. CC: OR = 3.90, 95% CI = 2.45-6.22, pH = 0.774). Similarly, the rs1410996 polymorphism also showed a rising AMD tendency (T vs. C: OR = 1.48, 95% CI = 1.17-1.87, pH < 0.001; TC vs. CC: OR = 1.52, 95% CI = 1.13-2.04, pH = 0.002; TT vs. CC: OR = 2.10, 95% CI = 1.27-3.49, pH < 0.001). What is more, subgroup analysis revealed that both polymorphisms indicated a high risk of nAMD (neovascular AMD) in Asian populations. CONCLUSIONS: This meta-analysis suggested that CFH rs1061170 and rs1410996 polymorphisms were associated with AMD risk, both of which demonstrated a higher susceptibility to AMD, especially to nAMD. However, the results of rs1410996 should be interpreted with caution due to the limited sample and heterogeneity. Large-scale and well-designed studies are needed to validate our findings.
BACKGROUND: With the increasing number of studies indicating that two single-nucleotide polymorphisms (SNPs), rs1061170 and rs1410996, in complement factor H (CFH) might be associated with the susceptibility to age-related macular degeneration (AMD), the exact association still remains uncertain. Thus, we conducted a meta-analysis to systematically summarize and clarify the association between the two SNPs and the AMD risk particularly in an Asian population. METHODS: A systematic search of studies on the association of two SNPs with the susceptibility to AMD was conducted in PubMed, Embase and Web of Science. Summary odds ratios (ORs) and 95% confidence intervals (CIs) of allele contrast and genotype contrast were estimated using the random or fixed effects model. The Q statistic test was used to identify heterogeneity, and the funnel plot was adopted to evaluate publication bias. A total of 19 case-control studies on rs1061170 and 8 studies on rs1410996 were included. RESULTS: Clearly a significantly increased trend of AMD was observed with the rs1061170 (T vs. C: OR = 1.91, 95% CI = 1.71-2.13, pH = 0.029; TC vs. CC: OR = 2.11, 95% CI = 1.30-3.42, pH = 0.792; TT vs. CC: OR = 3.90, 95% CI = 2.45-6.22, pH = 0.774). Similarly, the rs1410996 polymorphism also showed a rising AMD tendency (T vs. C: OR = 1.48, 95% CI = 1.17-1.87, pH < 0.001; TC vs. CC: OR = 1.52, 95% CI = 1.13-2.04, pH = 0.002; TT vs. CC: OR = 2.10, 95% CI = 1.27-3.49, pH < 0.001). What is more, subgroup analysis revealed that both polymorphisms indicated a high risk of nAMD (neovascular AMD) in Asian populations. CONCLUSIONS: This meta-analysis suggested that CFHrs1061170 and rs1410996 polymorphisms were associated with AMD risk, both of which demonstrated a higher susceptibility to AMD, especially to nAMD. However, the results of rs1410996 should be interpreted with caution due to the limited sample and heterogeneity. Large-scale and well-designed studies are needed to validate our findings.
Authors: Jamil M Neto; Marina Gm Viturino; Galina Ananina; Flávia F Bajano; Sueli M da S Costa; Alicia B Roque; Gessica Fs Borges; Raissa Franchi; Priscila Hh Rim; Flávio M Medina; Fernando F Costa; Mônica B de Melo; José Pc de Vasconcellos Journal: Exp Biol Med (Maywood) Date: 2021-07-07
Authors: Andrea Maugeri; Martina Barchitta; Maria Grazia Mazzone; Francesco Giuliano; Antonella Agodi Journal: Biomed Res Int Date: 2018-08-26 Impact factor: 3.411
Authors: Johanna M Seddon; James P Dossett; Rafael Widjajahakim; Bernard Rosner Journal: Invest Ophthalmol Vis Sci Date: 2019-10-01 Impact factor: 4.799