| Literature DB >> 26727375 |
Oluwatosin O Johnson1,2, Ming Zhao1, Jordan Gunn1, Bernard D Santarsiero3, Zhi-Qi Yin1,4, Gloria A Ayoola2, H A B Coker2, Chun-Tao Che1.
Abstract
Four new prenylated anthranols, harunganols C-F (1-4), along with kenganthranol A (5), harunganin (6), and ferruginin A (7), were identified from the leaves of Harungana madagascariensis. The structures of compounds 2, 5, and 7 were confirmed by single-crystal X-ray diffraction analysis. Compound 1 is a unique symmetrical anthranol dimer connected via a CH2 group. Compound 4 possesses a unique C-10 hemiketal group. All anthranols were evaluated for their α-glucosidase inhibitory activities. They displayed a higher potency compared to acarbose except for 3 and 4. In particular, harunganol C (1) showed an IC50 value of 1.2 μM.Entities:
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Year: 2016 PMID： 26727375 DOI： 10.1021/acs.jnatprod.5b00924
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050