Cyril R Pernet1, Krzysztof J Gorgolewski2, Dominic Job3, David Rodriguez3, Amos Storkey4, Ian Whittle5, Joanna Wardlaw3. 1. Brain Research Imaging Centre, The University of Edinburgh, UK; Centre for Clinical Brain Sciences, The University of Edinburgh, UK. Electronic address: cyril.pernet@ed.ac.uk. 2. Department of Psychology, Stanford University, Stanford, USA. 3. Brain Research Imaging Centre, The University of Edinburgh, UK; Centre for Clinical Brain Sciences, The University of Edinburgh, UK. 4. School of Informatics, The University of Edinburgh, UK. 5. Brain Research Imaging Centre, The University of Edinburgh, UK; Division of Clinical Neuroscience, NHS-Lothian, Edinburgh, UK.
Abstract
PURPOSE: Present and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients. METHODS: Protocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex. RESULTS: Using a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36). CONCLUSION: Providing that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery.
PURPOSE: Present and assess clinical protocols and associated automated workflow for pre-surgical functional magnetic resonance imaging in brain tumor patients. METHODS: Protocols were validated using a single-subject reliability approach based on 10 healthy control subjects. Results from the automated workflow were evaluated in 9 patients with brain tumors, comparing fMRI results to direct electrical stimulation (DES) of the cortex. RESULTS: Using a new approach to compute single-subject fMRI reliability in controls, we show that not all tasks are suitable in the clinical context, even if they show meaningful results at the group level. Comparison of the fMRI results from patients to DES showed good correspondence between techniques (odds ratio 36). CONCLUSION: Providing that validated and reliable fMRI protocols are used, fMRI can accurately delineate eloquent areas, thus providing an aid to medical decision regarding brain tumor surgery.
Authors: David G Ellis; Matthew L White; Satoru Hayasaka; David E Warren; Tony W Wilson; Michele R Aizenberg Journal: Neurosurg Focus Date: 2020-02-01 Impact factor: 4.047
Authors: Cyril R Pernet; Krzysztof J Gorgolewski; Dominic Job; David Rodriguez; Ian Whittle; Joanna Wardlaw Journal: Sci Data Date: 2016-02-02 Impact factor: 6.444