Literature DB >> 26725656

A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model.

Yaping Liu1, Huilong Ma1, Liangwei Zhang1, Yajing Cui1, Xiaoting Liu1, Jianguo Fang1.   

Abstract

The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.

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Year:  2016        PMID： 26725656     DOI： 10.1039/c5cc09998f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

Review 1.  Interplay between redox and protein homeostasis.

Authors:  Diogo R Feleciano; Kristin Arnsburg; Janine Kirstein
Journal:  Worm       Date:  2016-03-30

2.  Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells.

Authors:  Dongzhu Duan; Junmin Zhang; Juan Yao; Yaping Liu; Jianguo Fang
Journal:  J Biol Chem       Date:  2016-03-21       Impact factor: 5.157

3.  A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase.

Authors:  Tendai J Mafireyi; Madeleine Laws; John W Bassett; Pamela B Cassidy; Jorge O Escobedo; Robert M Strongin
Journal:  Angew Chem Int Ed Engl       Date:  2020-06-17       Impact factor: 16.823

4.  A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease.

Authors:  Liangwei Zhang; Shoujiao Peng; Jinyu Sun; Juan Yao; Jie Kang; Yuesong Hu; Jianguo Fang
Journal:  Chem Sci       Date:  2017-01-27       Impact factor: 9.825

5.  A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage.

Authors:  Xinming Li; Baoxin Zhang; Chaoxian Yan; Jin Li; Song Wang; Xiangxu Wei; Xiaoyan Jiang; Panpan Zhou; Jianguo Fang
Journal:  Nat Commun       Date:  2019-06-21       Impact factor: 14.919

6.  Cyclic 5-membered disulfides are not selective substrates of thioredoxin reductase, but are opened nonspecifically.

Authors:  Jan G Felber; Lena Poczka; Karoline C Scholzen; Lukas Zeisel; Martin S Maier; Sander Busker; Ulrike Theisen; Christina Brandstädter; Katja Becker; Elias S J Arnér; Julia Thorn-Seshold; Oliver Thorn-Seshold
Journal:  Nat Commun       Date:  2022-04-01       Impact factor: 14.919
  6 in total

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