| Literature DB >> 26725488 |
Adam Simon1, Yu-Hong Lam1, K N Houk1.
Abstract
The transition states of aldol reactions catalyzed by vicinal diamines are characterized with density functional calculations. It was found that a cyclic transition state involving a nine-membered hydrogen-bonded ring is preferred. The crown (chair-chair) conformations of the transition state account for the observed stereoselectivity of these reactions.Entities:
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Year: 2016 PMID： 26725488 DOI： 10.1021/jacs.5b12097
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419