Jung-Wan Yoo1, Kyung-Wook Jo2, Gu Young Park3, Tae Sun Shim4. 1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Gyeongsangnam-do, South Korea. 2. Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. 3. Public Health Center, Hapcheon-gun, Gyeongsangnam-do, South Korea. 4. Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. Electronic address: shimts@amc.seoul.kr.
Abstract
BACKGROUND: Latent tuberculosis infection (LTBI) rate is usually high in contacts with infectious TB patients. In TB-prevalent country, however, background LTBI rate is already high in general population. AIM: To compare the LTBI rate between controls and recognized close contacts. METHOD: Between February 2010 and January 2014, 183 controls and 376 contacts with TB infection were enrolled. The tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFT-GIT) were used to diagnose LTBI. RESULTS: Higher TST positivity was found in the control group than in the contact group (37.7% vs. 29.9%, P = 0.073). The positive QFT-GIT rate was higher in contacts than in controls (32.6% vs. 24.1%, P = 0.054). A significantly higher positive QFT-GIT rate was found in contacts under 30 years of age than in controls (16.1% vs. 0%, P = 0.005). CONCLUSION: In a TB-prevalent country, both TST and QFT-GIT were limited in the diagnosis of recent LTBI in adult contacts probably due to the high background LTBI rate. However, QFT-GIT seems to be better than TST in differentiating LTBI status in contacts younger than 30 year old.
BACKGROUND: Latent tuberculosis infection (LTBI) rate is usually high in contacts with infectious TBpatients. In TB-prevalent country, however, background LTBI rate is already high in general population. AIM: To compare the LTBI rate between controls and recognized close contacts. METHOD: Between February 2010 and January 2014, 183 controls and 376 contacts with TB infection were enrolled. The tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFT-GIT) were used to diagnose LTBI. RESULTS: Higher TST positivity was found in the control group than in the contact group (37.7% vs. 29.9%, P = 0.073). The positive QFT-GIT rate was higher in contacts than in controls (32.6% vs. 24.1%, P = 0.054). A significantly higher positive QFT-GIT rate was found in contacts under 30 years of age than in controls (16.1% vs. 0%, P = 0.005). CONCLUSION: In a TB-prevalent country, both TST and QFT-GIT were limited in the diagnosis of recent LTBI in adult contacts probably due to the high background LTBI rate. However, QFT-GIT seems to be better than TST in differentiating LTBI status in contacts younger than 30 year old.
Authors: Tan N Doan; Damon P Eisen; Morgan T Rose; Andrew Slack; Grace Stearnes; Emma S McBryde Journal: PLoS One Date: 2017-11-28 Impact factor: 3.240
Authors: Vanessa Lucília Silveira de Medeiros; Fabiana Cristina Fulco Santos; Lílian Maria Lapa Montenegro; Maria da Conceição Silva; Valdênia Maria Oliveira de Souza; Reginaldo Gonçalvez de Lima Neto; Líbia Cristina Rocha Vilela Moura; Vera Magalhães Journal: PLoS One Date: 2020-12-03 Impact factor: 3.240