| Literature DB >> 26725241 |
O Yu Kochetkova1,2, M M Yurinskaya3, M B Evgen'ev3,4, O G Zatsepina4, L I Shabarchina5, A V Suslikov6, S A Tikhonenko5, M G Vinokurov3.
Abstract
Microencapsulated heat shock proteins HSP 70 were studied in terms of their effects on neutrophil apoptosis, production of reactive oxygen species, and secretion of TNF-α by human neurtrophils and monocytes. Encapsulated HSP70 inhibited neutrophil apoptosis by 65% as compared to the effect of nonencapsulated HSP70; TNF-α production by the promonocytic THP-1 cells was similarly inhibited by the non-encapsulated and encapsulated HSP70. Thus, the polyelectrolyte micromolecules can be used as containers for effective delivery of HSP70 up to neutrophils and monocytes to correct the innate immunity functions.Entities:
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Year: 2016 PMID： 26725241 DOI： 10.1134/S001249661506006X
Source DB: PubMed Journal: Dokl Biol Sci ISSN： 0012-4966