Jia Wen1, Chen-Xian Guo2, Ming-Gen Lu3, Yao Lu2, Yun Huang4, Xing Liu1, Ying Li2, Zhi-Jun Huang2, Ya-Ping Zhang5, Hong Yuan6. 1. Department of Cardiology, The Third Xiang-Ya Hospital, Central South University, Changsha, China. 2. Center of Clinical Pharmacology, The Third Xiang-Ya Hospital, Central South University, 138 Tong-Zi-Po Road, 410013, Changsha, Hunan, People's Republic of China. 3. School of Community Health Sciences, University of Nevada, Reno, NV, USA. 4. School of Pharmacy, Central South University, Changsha, China. 5. The Pediatric Heart Center, Beijing Anzhen Hospital, Capital Medical University, 2 An-Zhen Road, 100029, Beijing, People's Republic of China. ping.zhang@hotmail.com. 6. Center of Clinical Pharmacology, The Third Xiang-Ya Hospital, Central South University, 138 Tong-Zi-Po Road, 410013, Changsha, Hunan, People's Republic of China. yhxy3yy@126.com.
Abstract
PURPOSE: Few studies have investigated the association between metabolic syndrome (MS) and chronic kidney disease in the elderly. Accordingly, the aim of this study was to examine the sex-specific association between MS and decreased glomerular filtration rate (GFR) in a Chinese elderly population. METHODS: We performed cross-sectional analyses of older (age ≥60 years) males (n = 19,015) and females (n = 23,310) classified as 0, 1, 2, 3, 4, and 5 component(s) or MS group based on the presenting MS component(s). Sex-specific relationship of decreased GFR with MS component(s) was analyzed by logistic regression models. RESULTS: Compared with participants with 0 component of MS, males with 1, 2, 3, 4, and 5 component(s) had 1.40-, 1.79-, 2.41-, 3.29-, and 4.09-fold risks for decreased GFR; females with 1, 2, 3, 4, and 5 component(s) had 1.65-, 1.71-, 1.88-, 2.32-, and 1.96-fold risks for decreased GFR, respectively. The multivariate-adjusted odds ratios for decreased GFR in males and females with MS compared with those without MS were 1.79 and 1.25, respectively. For participants without hypertension and diabetes, the association of MS with decreased GFR was still significant. CONCLUSIONS: In this study of 42,325 Chinese participants aged ≥60 years, MS was significantly associated with decreased GFR, and the association was more profound for males than females.
PURPOSE: Few studies have investigated the association between metabolic syndrome (MS) and chronic kidney disease in the elderly. Accordingly, the aim of this study was to examine the sex-specific association between MS and decreased glomerular filtration rate (GFR) in a Chinese elderly population. METHODS: We performed cross-sectional analyses of older (age ≥60 years) males (n = 19,015) and females (n = 23,310) classified as 0, 1, 2, 3, 4, and 5 component(s) or MS group based on the presenting MS component(s). Sex-specific relationship of decreased GFR with MS component(s) was analyzed by logistic regression models. RESULTS: Compared with participants with 0 component of MS, males with 1, 2, 3, 4, and 5 component(s) had 1.40-, 1.79-, 2.41-, 3.29-, and 4.09-fold risks for decreased GFR; females with 1, 2, 3, 4, and 5 component(s) had 1.65-, 1.71-, 1.88-, 2.32-, and 1.96-fold risks for decreased GFR, respectively. The multivariate-adjusted odds ratios for decreased GFR in males and females with MS compared with those without MS were 1.79 and 1.25, respectively. For participants without hypertension and diabetes, the association of MS with decreased GFR was still significant. CONCLUSIONS: In this study of 42,325 Chinese participants aged ≥60 years, MS was significantly associated with decreased GFR, and the association was more profound for males than females.
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