Young Jin Tak1,2, Dong Wook Jeong3,4,5, Yun Jin Kim1,2, Sang Yeoup Lee6, Jeong Gyu Lee1,2, Sang Heon Song7, Kwang Soo Cha8, Yang Ho Kang9,10. 1. Department of Family Medicine, Pusan National University School of Medicine, Busan, Republic of Korea. 2. Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. 3. Department of Family Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. dwjeong75@hanmail.net. 4. Medical Research Institute, Pusan National University School of Medicine, Yangsan, Republic of Korea. dwjeong75@hanmail.net. 5. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. dwjeong75@hanmail.net. 6. Medical Education Unit, Pusan National University School of Medicine, Yangsan, Republic of Korea. 7. Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea. 8. Department of Cardiology and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. 9. Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. 10. Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Abstract
PURPOSE: High levels of serum total homocysteine (tHcy), often observed in chronic kidney disease (CKD) patients, are a risk factor for cardiovascular disease. However, little is known about the relationship between tHcy and renal function in healthy individuals. We examined whether tHcy levels are related to renal function in Asian individuals without CKD. METHODS: This cross-sectional study examined 2032 subjects, aged 40-64 years. Individuals with kidney diseases or other conditions that could affect tHcy were excluded. Renal function was determined by estimated glomerular filtration rate (eGFR) from levels of serum creatinine (sCr) and cystatin C. RESULTS: Age, tHcy, sCr, and cystatin C of the subjects were 54.1 ± 6.0 years, 9.5 (8.0-11.4) μmol/L, 0.81 ± 0.1 mg/dL, and 0.82 ± 0.1 mg/L, respectively. In a multiple linear regression analysis, tHcy was a significant independent determinant of sCr and cystatin C in men (β = 0.206 and β = 0.282, respectively) and women (β = 0.247 and β = 0.229, respectively). Highest tHcy levels were independently associated with increased cystatin C (>s1.10 mg/L) with an odds ratio (OR) of 5.00 [95% confidence interval (CI) 2.81-8.09] and decreased eGFR (<90 mL/min/1.73 m(2)) with an OR of 1.69 (95% CI 1.36-2.11) compared to tHcy levels in the 1st-3rd quartiles. CONCLUSIONS: Higher levels of tHcy are independently associated with sCr and cystatin C elevation. Our study suggests that tHcy levels may be influenced by renal function in Asian populations without CKD. Future studies are needed to define the role of tHcy in renal function.
PURPOSE: High levels of serum total homocysteine (tHcy), often observed in chronic kidney disease (CKD) patients, are a risk factor for cardiovascular disease. However, little is known about the relationship between tHcy and renal function in healthy individuals. We examined whether tHcy levels are related to renal function in Asian individuals without CKD. METHODS: This cross-sectional study examined 2032 subjects, aged 40-64 years. Individuals with kidney diseases or other conditions that could affect tHcy were excluded. Renal function was determined by estimated glomerular filtration rate (eGFR) from levels of serum creatinine (sCr) and cystatin C. RESULTS: Age, tHcy, sCr, and cystatin C of the subjects were 54.1 ± 6.0 years, 9.5 (8.0-11.4) μmol/L, 0.81 ± 0.1 mg/dL, and 0.82 ± 0.1 mg/L, respectively. In a multiple linear regression analysis, tHcy was a significant independent determinant of sCr and cystatin C in men (β = 0.206 and β = 0.282, respectively) and women (β = 0.247 and β = 0.229, respectively). Highest tHcy levels were independently associated with increased cystatin C (>s1.10 mg/L) with an odds ratio (OR) of 5.00 [95% confidence interval (CI) 2.81-8.09] and decreased eGFR (<90 mL/min/1.73 m(2)) with an OR of 1.69 (95% CI 1.36-2.11) compared to tHcy levels in the 1st-3rd quartiles. CONCLUSIONS: Higher levels of tHcy are independently associated with sCr and cystatin C elevation. Our study suggests that tHcy levels may be influenced by renal function in Asian populations without CKD. Future studies are needed to define the role of tHcy in renal function.
Authors: Vandana Menon; Xuelei Wang; Tom Greene; Gerald J Beck; John W Kusek; Jacob Selhub; Andrew S Levey; Mark J Sarnak Journal: Kidney Int Date: 2005-04 Impact factor: 10.612
Authors: A Gibson; J V Woodside; I S Young; P C Sharpe; C Mercer; C C Patterson; M C McKinley; L A J Kluijtmans; A S Whitehead; A Evans Journal: QJM Date: 2008-09-12
Authors: Jung In Choi; Young Hye Cho; Sang Yeoup Lee; Dong Wook Jeong; Jeong Gyu Lee; Yu Hyeon Yi; Young Jin Tak; Seung Hun Lee; Hye Rim Hwang; Eun Ju Park Journal: Korean J Fam Med Date: 2019-05-10