Raquel López-Mejías1, Fernanda Genre1, Sara Remuzgo-Martínez1, Gema Robledo2, Javier Llorca3, Alfonso Corrales1, Carlos González-Juanatey4, Begoña Ubilla1, Verónica Mijares1, Trinitario Pina1, Ricardo Blanco1, Santos Castañeda5, Javier Martín2, Miguel A González-Gay6. 1. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Department, IDIVAL, Santander, Spain. 2. Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain. 3. Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain. 4. Cardiology Department, Hospital Lucus Augusti, Lugo, Spain. 5. Rheumatology Department, Hospital Universitario la Princesa, IIS-Princesa, Madrid, Spain. 6. Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Department, IDIVAL, Santander, Spain; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Health Research Institute of Santiago de Compostela (IDIS), Division of Rheumatology, Clinical University Hospital of Santiago de Compostela, Santiago de Compostela, Spain. Electronic address: miguelaggay@hotmail.com.
Abstract
INTRODUCTION: An association between the vitamin D receptor (VDR) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described. Since cardiovascular mortality in rheumatoid arthritis (RA) is comparable to that observed for patients with type-2 diabetes, we aimed to determine if VDR GAT haplotype is also associated with atherosclerotic disease in RA. MATERIAL AND METHODS: 591 Northern Spanish RA patients were genotyped for 4 VDR polymorphisms (rs731236 A/G; rs7975232 A/C; rs1544410C/T; rs2228570 G/A). Atherosclerotic disease was established by the presence of carotid plaques in carotid ultrasound. RESULTS: VDR rs7975232 AA genotype was increased in RA patients with plaques (p = 0.045, OR = 1.46 [1.01-2.18]). More importantly, the frequency of carotid plaques was significantly increased in RA patients who carried the GATG haplotype (p = 0.009, OR = 1.56 [1.09-2.42]). CONCLUSION: Our results suggest a potential VDR GATG haplotype association with atherosclerotic disease in RA patients.
INTRODUCTION: An association between the vitamin D receptor (VDR) GAT haplotype and coronary artery disease (CAD) in type-2 diabetes has recently been described. Since cardiovascular mortality in rheumatoid arthritis (RA) is comparable to that observed for patients with type-2 diabetes, we aimed to determine if VDRGAT haplotype is also associated with atherosclerotic disease in RA. MATERIAL AND METHODS: 591 Northern Spanish RApatients were genotyped for 4 VDR polymorphisms (rs731236 A/G; rs7975232 A/C; rs1544410C/T; rs2228570 G/A). Atherosclerotic disease was established by the presence of carotid plaques in carotid ultrasound. RESULTS:VDRrs7975232 AA genotype was increased in RApatients with plaques (p = 0.045, OR = 1.46 [1.01-2.18]). More importantly, the frequency of carotid plaques was significantly increased in RApatients who carried the GATG haplotype (p = 0.009, OR = 1.56 [1.09-2.42]). CONCLUSION: Our results suggest a potential VDR GATG haplotype association with atherosclerotic disease in RApatients.
Authors: Raquel López-Mejías; Fernanda Genre; Sara Remuzgo-Martínez; Carlos González-Juanatey; Montserrat Robustillo-Villarino; Javier Llorca; Alfonso Corrales; Esther Vicente; José A Miranda-Filloy; César Magro; Beatriz Tejera-Segura; Marco A Ramírez Huaranga; Trinitario Pina; Ricardo Blanco; Juan J Alegre-Sancho; Enrique Raya; Verónica Mijares; Begoña Ubilla; María D Mínguez Sánchez; Carmen Gómez-Vaquero; Alejandro Balsa; Dora Pascual-Salcedo; Francisco J López-Longo; Patricia Carreira; Isidoro González-Álvaro; Luis Rodríguez-Rodríguez; Benjamín Fernández-Gutiérrez; Iván Ferraz-Amaro; Santos Castañeda; Javier Martín; Miguel A González-Gay Journal: Sci Rep Date: 2016-08-18 Impact factor: 4.379
Authors: Alicja E Grzegorzewska; Monika K Świderska; Adrianna Mostowska; Wojciech Warchoł; Paweł P Jagodziński Journal: Int J Endocrinol Date: 2016-08-23 Impact factor: 3.257