Hironobu Tokumasu1,2,3, Satoko Tokumasu3, Koji Kawakami1. 1. Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan. 2. Department of Consultation, Kurashiki Clinical Research Institute, Okayama, Japan. 3. Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan.
Abstract
BACKGROUND: The relationship between chorioamnionitis (CAM) and neonatal mortality has been extensively investigated, but that of maternal pre-eclampsia and neonatal mortality is unclear. We investigated neonatal mortality and morbidity of maternal pre-eclampsia and clinical CAM in extremely premature infants using data from a population-based cohort study. METHODS: We retrospectively analyzed data obtained from the Neonatal Research Network in Japan, a population-based cohort study (n = 18 900) conducted to clarify the clinical characteristics and morbidity of very low-birthweight infants. Patients were divided into four diagnosis-based groups for comparative analysis: sole pre-eclampsia; sole clinical CAM; concurrent pre-eclampsia and clinical CAM; and non-diagnosis (of pre-eclampsia and clinical CAM). RESULTS: Mortality was higher in the pre-eclampsia groups compared with the groups without (18.3%, 84/459 vs 14.0%, 567/4059; OR, 1.38; 95%CI: 1.07-1.78). In contrast, mortality was not affected by presence of clinical CAM (with, 13.7% 182/1328 vs without, 15.0% 469/3190; OR, 0.92; 95%CI: 0.77-1.11). With regard to small for gestational age, the mortality rate increased by two-three-fold as gestational week decreased. The complication survival rate in the whole group was 35% (1135/3218). CONCLUSIONS: Maternal pre-eclampsia is associated with poor prognosis in extremely premature infants. We also need to deliberate on the trade-off between the advantages of early rescue from pre-eclampsia and risk of prematurity.
BACKGROUND: The relationship between chorioamnionitis (CAM) and neonatal mortality has been extensively investigated, but that of maternal pre-eclampsia and neonatal mortality is unclear. We investigated neonatal mortality and morbidity of maternal pre-eclampsia and clinical CAM in extremely premature infants using data from a population-based cohort study. METHODS: We retrospectively analyzed data obtained from the Neonatal Research Network in Japan, a population-based cohort study (n = 18 900) conducted to clarify the clinical characteristics and morbidity of very low-birthweight infants. Patients were divided into four diagnosis-based groups for comparative analysis: sole pre-eclampsia; sole clinical CAM; concurrent pre-eclampsia and clinical CAM; and non-diagnosis (of pre-eclampsia and clinical CAM). RESULTS: Mortality was higher in the pre-eclampsia groups compared with the groups without (18.3%, 84/459 vs 14.0%, 567/4059; OR, 1.38; 95%CI: 1.07-1.78). In contrast, mortality was not affected by presence of clinical CAM (with, 13.7% 182/1328 vs without, 15.0% 469/3190; OR, 0.92; 95%CI: 0.77-1.11). With regard to small for gestational age, the mortality rate increased by two-three-fold as gestational week decreased. The complication survival rate in the whole group was 35% (1135/3218). CONCLUSIONS: Maternal pre-eclampsia is associated with poor prognosis in extremely premature infants. We also need to deliberate on the trade-off between the advantages of early rescue from pre-eclampsia and risk of prematurity.
Authors: A Razak; A Florendo-Chin; L Banfield; M G Abdul Wahab; S McDonald; P S Shah; A Mukerji Journal: J Perinatol Date: 2017-11-02 Impact factor: 2.521
Authors: Sonali Chaudhury; Juanita Saqibuddin; Robert Birkett; Kate Falcon-Girard; Morey Kraus; Linda M Ernst; William Grobman; Karen K Mestan Journal: Front Pediatr Date: 2019-11-14 Impact factor: 3.418