Literature DB >> 2672445

Post-translational modifications of proteins: some problems left to solve.

S C Yan, B W Grinnell, F Wold.   

Abstract

Three major questions regarding the post-translational modification of amino acid side chains in proteins are briefly considered: (1) What are the biological functions of the reactions, (2) what is the specificity of the processing reactions in selecting only a few or sometimes even only one residue for modification, and (3) how do we solve the uniqueness of the processing steps in the production of recombinant proteins? The answers to these questions are not obvious at this time.

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Year:  1989        PMID： 2672445     DOI： 10.1016/0968-0004(89)90060-1

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  8 in total

Review 1.  Post-translational modifications of lantibiotics.

Authors:  T Kupke; F Götz
Journal:  Antonie Van Leeuwenhoek       Date:  1996-02       Impact factor: 2.271

2.  Ping-pong amplification of a retroviral vector achieves high-level gene expression: human growth hormone production.

Authors:  S L Kozak; D Kabat
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

Review 3.  The sentinel within: exploiting the immune system for cancer biomarkers.

Authors:  Karen S Anderson; Joshua LaBaer
Journal:  J Proteome Res       Date:  2005 Jul-Aug       Impact factor: 4.466

4.  N-terminal acetylation and protonation of individual hemoglobin subunits: position-dependent effects on tetramer strength and cooperativity.

Authors:  Makoto Ashiuchi; Takeshi Yagami; Ronald J Willey; Julio C Padovan; Brian T Chait; Anthony Popowicz; Lois R Manning; James M Manning
Journal:  Protein Sci       Date:  2005-06       Impact factor: 6.725

5.  Comparison of N-Glycan Pattern of Recombinant Human Coagulation Factors II and IX Expressed in Chinese Hamster Ovary (CHO) and African Green Monkey (Vero) Cells.

Authors: 
Journal:  J Thromb Thrombolysis       Date:  1996       Impact factor: 2.300

6.  Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin.

Authors:  R Drews; R K Paleyanda; T K Lee; R R Chang; A Rehemtulla; R J Kaufman; W N Drohan; H Luboń
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

Review 7.  Steroid receptor domain conformations and hormone antagonism.

Authors:  M K Agarwal
Journal:  Naturwissenschaften       Date:  1994-03

8.  Inefficient processing of human protein C in the mouse mammary gland.

Authors:  W N Drohan; D W Zhang; R K Paleyanda; R Chang; M Wroble; W Velander; H Lubon
Journal:  Transgenic Res       Date:  1994-11       Impact factor: 2.788
  8 in total

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