BACKGROUND: Non-motor symptoms (NMS) are gaining increasing relevance in the management of Parkinson's disease (PD), but little is known about their progression, especially among patients with different ages. METHODS: A total of 117 PD patients who were divided into four age groups (<50, 50-60, 60-70, and >70years old) were included to assess NMS at baseline and follow-up visit (21.6±5.6months). The frequency and severity of NMS were assessed using the Non-Motor Symptom Scale (NMSS). RESULTS: After adjusting for confounding factors, patients at the last visit had significantly higher frequency of "Difficulty falling asleep" item (p=0.034) and "Urinary" domain (p=0.017), and higher total NMSS score (p=0.011) as well as scores for "Sleep/fatigue" (p=0.013) and "Sexual dysfunction" (p=0.014) domains and scores for "Fatigue" (p=0.004), "Lack of motivation" (p=0.033), "Interest in sex" (p=0.014) and "Problems having sex" (p=0.031) items than patients at baseline. The frequency changes of each NMS among four age groups exhibited an anfractuous result, while the annual severity changes of each NMS were not significant different among four age groups. Multinomial logistic regression model indicated that age had no correlation with the changes of NMS frequency and severity. CONCLUSIONS: The severity of NMS in PD tends to become progressively worse with the course of the disease. Age is not related to the progression of NMS in PD.
BACKGROUND: Non-motor symptoms (NMS) are gaining increasing relevance in the management of Parkinson's disease (PD), but little is known about their progression, especially among patients with different ages. METHODS: A total of 117 PDpatients who were divided into four age groups (<50, 50-60, 60-70, and >70years old) were included to assess NMS at baseline and follow-up visit (21.6±5.6months). The frequency and severity of NMS were assessed using the Non-Motor Symptom Scale (NMSS). RESULTS: After adjusting for confounding factors, patients at the last visit had significantly higher frequency of "Difficulty falling asleep" item (p=0.034) and "Urinary" domain (p=0.017), and higher total NMSS score (p=0.011) as well as scores for "Sleep/fatigue" (p=0.013) and "Sexual dysfunction" (p=0.014) domains and scores for "Fatigue" (p=0.004), "Lack of motivation" (p=0.033), "Interest in sex" (p=0.014) and "Problems having sex" (p=0.031) items than patients at baseline. The frequency changes of each NMS among four age groups exhibited an anfractuous result, while the annual severity changes of each NMS were not significant different among four age groups. Multinomial logistic regression model indicated that age had no correlation with the changes of NMS frequency and severity. CONCLUSIONS: The severity of NMS in PD tends to become progressively worse with the course of the disease. Age is not related to the progression of NMS in PD.
Authors: Paulo Bugalho; Filipa Ladeira; Raquel Barbosa; João P Marto; Claudia Borbinha; Laurete da Conceição; Manuel Salavisa; Marlene Saraiva; Bruna Meira; Marco Fernandes Journal: Mov Disord Clin Pract Date: 2021-06-19
Authors: Daniel J van Wamelen; Anna Sauerbier; Valentina Leta; Carmen Rodriguez-Blazquez; Cristian Falup-Pecurariu; Mayela Rodriguez-Violante; Alexandra Rizos; Y Tsuboi; Vinod Metta; Roongroj Bhidayasiri; Kalyan Bhattacharya; Rupam Borgohain; L K Prashanth; Raymond Rosales; Simon Lewis; Victor Fung; Madhuri Behari; Vinay Goyal; Asha Kishore; Santiago Perez Lloret; Pablo Martinez-Martin; K Ray Chaudhuri Journal: Sci Rep Date: 2021-05-05 Impact factor: 4.379
Authors: Diego Santos García; Teresa de Deus Fonticoba; Carlos Cores; Guillermo Muñoz; Jose M Paz González; Cristina Martínez Miró; Ester Suárez; Silvia Jesús; Miquel Aguilar; Pau Pastor; Lluis Planellas; Marina Cosgaya; Juan García Caldentey; Nuria Caballol; Inés Legarda; Jorge Hernández Vara; Iria Cabo; Luis López Manzanares; Isabel González Aramburu; María A Ávila Rivera; Maria J Catalán; Víctor Nogueira; Víctor Puente; María Ruíz de Arcos; Carmen Borrué; Berta Solano Vila; María Álvarez Sauco; Lydia Vela; Sonia Escalante; Esther Cubo; Francisco Carrillo Padilla; Juan C Martínez Castrillo; Pilar Sánchez Alonso; Maria G Alonso Losada; Nuria López Ariztegui; Itziar Gastón; Pedro Clavero; Jaime Kulisevsky; Marta Blázquez Estrada; Manuel Seijo; Javier Rúiz Martínez; Caridad Valero; Mónica Kurtis; Oriol de Fábregues; Jessica González Ardura; Carlos Ordás; Luis M López Díaz; Darrian McAfee; Pablo Martinez-Martin; Pablo Mir Journal: NPJ Parkinsons Dis Date: 2021-12-16
Authors: Mayela Rodríguez-Violante; Alonso Alvarado-Bolaños; Amin Cervantes-Arriaga; Pablo Martinez-Martin; Alexandra Rizos; K Ray Chaudhuri Journal: Mov Disord Clin Pract Date: 2017-02-06
Authors: Diego Santos-García; Teresa de Deus; Carlos Cores; Hector Canfield; Jose M Paz González; Cristina Martínez Miró; Lorena Valdés Aymerich; Ester Suárez; Silvia Jesús; Miquel Aguilar; Pau Pastor; Lluis Planellas; Marina Cosgaya; Juan García Caldentey; Nuria Caballol; Ines Legarda; Jorge Hernández-Vara; Iria Cabo; Lydia López Manzanares; Isabel González Aramburu; Maria A Ávila Rivera; Maria J Catalán; Victor Nogueira; Victor Puente; Julio Dotor; Carmen Borrué; Berta Solano; Maria Álvarez Sauco; Lydia Vela; Sonia Escalante; Esther Cubo; Francisco Carrillo; Juan C Martínez Castrillo; Pilar Sánchez Alonso; Gemma Alonso; Nuria López Ariztegui; Itziar Gastón; Jaime Kulisevsky; Marta Blázquez; Manuel Seijo; Javier Rúiz Martínez; Caridad Valero; Monica Kurtis; Oriol de Fábregues; Jessica Ardura; Ruben Alonso; Carlos Ordás; Luis M López Díaz; Darrian McAfee; Pablo Martinez-Martin; Pablo Mir Journal: J Pers Med Date: 2021-06-30