Literature DB >> 26723543

Glycine transporter2 inhibitors: Getting the balance right.

Robert J Vandenberg1, Shannon N Mostyn2, Jane E Carland2, Renae M Ryan2.   

Abstract

Neurotransmitter transporters are targets for a wide range of therapeutically useful drugs. This is because they have the capacity to selectively manipulate the dynamics of neurotransmitter concentrations and thereby enhance or diminish signalling through particular brain pathways. High affinity glycine transporters (GlyTs) regulate extracellular concentrations of glycine and provide novel therapeutic targets for neurological disorders. Crown
Copyright © 2016. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Glycine neurotransmission; Glycine transport; Glycine transport inhibitors; Pain

Mesh：

Substances：

Year:  2015        PMID： 26723543     DOI： 10.1016/j.neuint.2015.12.007

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  6 in total

Review 1.  Allosteric Modulation of Neurotransmitter Transporters as a Therapeutic Strategy.

Authors:  Marco Niello; Ralph Gradisch; Claus Juul Loland; Thomas Stockner; Harald H Sitte
Journal:  Trends Pharmacol Sci       Date:  2020-05-26       Impact factor: 14.819

2.  Glycinergic Transmission in the Presence and Absence of Functional GlyT2: Lessons From the Auditory Brainstem.

Authors:  Sina E Brill; Ayse Maraslioglu; Catharina Kurz; Florian Kramer; Martin F Fuhr; Abhyudai Singh; Eckhard Friauf
Journal:  Front Synaptic Neurosci       Date:  2021-02-09

Review 3.  Inhibition of Glycine Re-Uptake: A Potential Approach for Treating Pain by Augmenting Glycine-Mediated Spinal Neurotransmission and Blunting Central Nociceptive Signaling.

Authors:  Christopher L Cioffi
Journal:  Biomolecules       Date:  2021-06-10

4.  Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2.

Authors:  Shannon N Mostyn; Subhodeep Sarker; Parthasarathy Muthuraman; Arun Raja; Susan Shimmon; Tristan Rawling; Christopher L Cioffi; Robert J Vandenberg
Journal:  ACS Chem Neurosci       Date:  2020-04-09       Impact factor: 4.418

5.  Structural Determinants of the Neuronal Glycine Transporter 2 for the Selective Inhibitors ALX1393 and ORG25543.

Authors:  Cristina Benito-Muñoz; Almudena Perona; Raquel Felipe; Gonzalo Pérez-Siles; Enrique Núñez; Carmen Aragón; Beatriz López-Corcuera
Journal:  ACS Chem Neurosci       Date:  2021-05-18       Impact factor: 4.418

6.  The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure-Function Relationships in Mammalian SLC6 Transporters.

Authors:  Michela Castagna; Raffaella Cinquetti; Tiziano Verri; Francesca Vacca; Matteo Giovanola; Amilcare Barca; Tiziana Romanazzi; Cristina Roseti; Alessandra Galli; Elena Bossi
Journal:  Neurochem Res       Date:  2021-07-24       Impact factor: 3.996
  6 in total

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