Li Li1, Gen-Long Jiao2, Shuang Qin3, Qing Xiao3. 1. Shenzhen Guangming New District Center Hospital Shenzhen, Guangdong, China. 2. The First Affliated Hospital of Jinan University Guangzhou, Guangdong, China. 3. Guangzhou Women and Children's Medical Center Guangzhou, Guangdong Province, China.
Abstract
PURPOSE: To analyze the correlation of the polymorphisms of human wing-apart like (hWAPL) gene (rs7083506 and rs11202058) with the susceptibility to cervical cancer. Besides, the relationship of haplotypes between the polymorphisms with cervical cancer susceptibility was analyzed. METHODS: Taqman probe genotyping method was adopted to detect the genotype distribution of hWAPL rs7083506 and rs11202058 polymorphisms in 117 cervical cancer patients and 128 healthy controls. Linkage disequilibrium and haplotypes were analyzed by Haploview software. χ(2) test was utilized to analyze the differences of genotype, allele and haplotype frequencies between the case and control groups. RESULTS: Correlation analysis of hWAPL rs7083506 and rs11202058 polymorphisms with cervical cancer susceptibility was based on the five genetic models. TT genotype of rs7083506 increased the susceptibility of cervical cancer in TT vs. CC model and TT vs. CT+TT model (OR=2.249, 95% CI=1.018-4.970; OR=2.287, 95% CI=1.069-4.896). For rs11202058, the A allele increased the cervical cancer susceptibility (A vs. G, OR=1.502, 95% CI=1.005-2.245). No significant correlation was observed between rs11202058 genotypes and cervical cancer susceptibility. We performed the haplotype analysis between the two polymorphisms, and found that T-A haplotype significantly correlated with cervical cancer, the susceptibility of cervical cancer increased to 1.78 times. CONCLUSIONS: Rs7083506 and rs11202058 polymorphisms of hWAPL and their haplotype T-A were associated with cervical cancer.
PURPOSE: To analyze the correlation of the polymorphisms of human wing-apart like (hWAPL) gene (rs7083506 and rs11202058) with the susceptibility to cervical cancer. Besides, the relationship of haplotypes between the polymorphisms with cervical cancer susceptibility was analyzed. METHODS: Taqman probe genotyping method was adopted to detect the genotype distribution of hWAPLrs7083506 and rs11202058 polymorphisms in 117 cervical cancerpatients and 128 healthy controls. Linkage disequilibrium and haplotypes were analyzed by Haploview software. χ(2) test was utilized to analyze the differences of genotype, allele and haplotype frequencies between the case and control groups. RESULTS: Correlation analysis of hWAPLrs7083506 and rs11202058 polymorphisms with cervical cancer susceptibility was based on the five genetic models. TT genotype of rs7083506 increased the susceptibility of cervical cancer in TT vs. CC model and TT vs. CT+TT model (OR=2.249, 95% CI=1.018-4.970; OR=2.287, 95% CI=1.069-4.896). For rs11202058, the A allele increased the cervical cancer susceptibility (A vs. G, OR=1.502, 95% CI=1.005-2.245). No significant correlation was observed between rs11202058 genotypes and cervical cancer susceptibility. We performed the haplotype analysis between the two polymorphisms, and found that T-A haplotype significantly correlated with cervical cancer, the susceptibility of cervical cancer increased to 1.78 times. CONCLUSIONS:Rs7083506 and rs11202058 polymorphisms of hWAPL and their haplotype T-A were associated with cervical cancer.
Authors: Nubia Muñoz; F Xavier Bosch; Silvia de Sanjosé; Rolando Herrero; Xavier Castellsagué; Keerti V Shah; Peter J F Snijders; Chris J L M Meijer Journal: N Engl J Med Date: 2003-02-06 Impact factor: 91.245
Authors: Anton H N Hopman; Frank Smedts; Wendy Dignef; Monique Ummelen; Gabe Sonke; Marcel Mravunac; G Peter Vooijs; Ernst-Jan M Speel; Frans C S Ramaekers Journal: J Pathol Date: 2004-01 Impact factor: 7.996