| Literature DB >> 26722559 |
Qin Su1, Hongsheng Liu1, Xian Zhang1, Wei Dang1, Runmei Liu2, Xiaodong Zhao1, Xiaoling Yuan1, Yuhong Qin1, Jianbo Zhang1, Chunming Chen1, Yunfeng Xia2.
Abstract
The study aims to evaluate a rapid testing of NT-proBNP in differential diagnosis of cardiac and pulmonary dyspnea among elderly emergency patients. Two hundred sixty-eight dyspnea patients with ages of ≥60 years old participated in the study. Based on their clinical diagnosis, the patients were divided into three groups: group A diagnosed with pulmonary dyspnea (PD), group B diagnosed with congestive heart failure (CHF), and group C diagnosed with combined dyspnea (CHF+PD). NT-proBNP levels among the three groups were compared. NT-proBNP levels in group A were significantly lower than those in groups B and C. No significant difference was observed between groups B and C in terms of NT-proBNP levels (P>0.05). Our data showed that NT-proBNP levels in patients with cardiac dyspnea were significantly higher than those in patients with pulmonary dyspnea. Person linear association analysis revealed that NT-proBNP levels were reversely associated with LVEF (r=-0.675, P<0.01), indicating that higher NT-proBNP levels result in lower LVEF and poorer heart functions. NT-proBNP is a valuable biomarker in differential diagnosis of pulmonary and cardiac dyspnea among elderly patients due to the high sensitivity of the testing method and the strong association with the severity of heart failure.Entities:
Keywords: Amino-terminal pro-B-type natriuretic peptide; biomarker; dyspnea; elderly patients; emergency
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Year: 2015 PMID： 26722559 PMCID： PMC4680504
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625