OBJECTIVE: In order to investigate whether CARD9 gene is associated with IBD in Chinese Han population, we replicated 2 SNPs of CARD9 which have been reported to be significantly associated with IBD. METHODS: Two SNPs were genotyped using polymerase chain reaction with sequence-specific primers in 288 patients (232 CD patients, 56 UC patients) and 274 controls. RESULTS: The frequencies and distributions of alleles and genotypes of the tested SNPs were analyzed, and no significant differences were found between patients and controls. CONCLUSIONS: We observed no significant association between the investigated CARD9 SNPs and the susceptibility of either CD or UC. Further studies with larger sample size focusing on different ethnicities are required to elucidate the correlation between CARD9 and IBD.
OBJECTIVE: In order to investigate whether CARD9 gene is associated with IBD in Chinese Han population, we replicated 2 SNPs of CARD9 which have been reported to be significantly associated with IBD. METHODS: Two SNPs were genotyped using polymerase chain reaction with sequence-specific primers in 288 patients (232 CDpatients, 56 UC patients) and 274 controls. RESULTS: The frequencies and distributions of alleles and genotypes of the tested SNPs were analyzed, and no significant differences were found between patients and controls. CONCLUSIONS: We observed no significant association between the investigated CARD9 SNPs and the susceptibility of either CD or UC. Further studies with larger sample size focusing on different ethnicities are required to elucidate the correlation between CARD9 and IBD.
Authors: Alessandra Geremia; Paolo Biancheri; Philip Allan; Gino R Corazza; Antonio Di Sabatino Journal: Autoimmun Rev Date: 2013-06-15 Impact factor: 9.754
Authors: Alexandra Zhernakova; Eleanora M Festen; Lude Franke; Gosia Trynka; Cleo C van Diemen; Alienke J Monsuur; Marianna Bevova; Rian M Nijmeijer; Ruben van 't Slot; Roel Heijmans; H Marike Boezen; David A van Heel; Adriaan A van Bodegraven; Pieter C F Stokkers; Cisca Wijmenga; J Bart A Crusius; Rinse K Weersma Journal: Am J Hum Genet Date: 2008-04-24 Impact factor: 11.025
Authors: Manuel A Rivas; Mélissa Beaudoin; Agnes Gardet; Christine Stevens; Yashoda Sharma; Clarence K Zhang; Gabrielle Boucher; Stephan Ripke; David Ellinghaus; Noel Burtt; Tim Fennell; Andrew Kirby; Anna Latiano; Philippe Goyette; Todd Green; Jonas Halfvarson; Talin Haritunians; Joshua M Korn; Finny Kuruvilla; Caroline Lagacé; Benjamin Neale; Ken Sin Lo; Phil Schumm; Leif Törkvist; Marla C Dubinsky; Steven R Brant; Mark S Silverberg; Richard H Duerr; David Altshuler; Stacey Gabriel; Guillaume Lettre; Andre Franke; Mauro D'Amato; Dermot P B McGovern; Judy H Cho; John D Rioux; Ramnik J Xavier; Mark J Daly Journal: Nat Genet Date: 2011-10-09 Impact factor: 38.330