| Literature DB >> 26722504 |
Wei Shi1, Jiangfeng Hu2, Shizhang Zhu3, Xiaoying Shen3, Xiaoyan Zhang3, Changqing Yang2, Hengjun Gao4, Hao Zhang1.
Abstract
The aim of this study was to investigate the relationship among MTA2, Ki-67 and HCC patient prognosis. Tissue microarray and immunohistochemistry were used to detect the expression of MTA2 and Ki-67 in HCC samples and corresponding adjacent samples. We found MTA2 and Ki-67 were both increased in HCC tissues than those in adjacent tissues and nuclear MTA2 was associated with Ki-67 (P = 0.019). Moreover, nuclear MTA2 was a risk factor of distant metastasis in patients with HCC andKi-67 showed a negative correlation with histological grade (P < 0.05, P < 0.01, respectively). Multivariate Cox model analysis revealed that Ki-67 expression was an independent prognosis factor in HCC patients (P = 0.020). These results indicated there might be a tight correlation among MTA2, Ki-67 and HCC prognosis. MTA2 combined with Ki-67 might be used to predict HCC patient prognosis.Entities:
Keywords: HCC; Ki-67; MTA2; liver cancer
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Year: 2015 PMID： 26722504 PMCID： PMC4680449
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625