Literature DB >> 26722502

Effect of caveolin-1 on the expression of tight junction-associated proteins in rat glioma-derived microvascular endothelial cells.

Yao Li1, Li-Bo Liu1, Teng Ma1, Ping Wang1, Yi-Xue Xue1.   

Abstract

Caveolin-1 affects the permeability of blood-tumor barrier (BTB) by regulating the expression of tight junction-associated proteins. However, the effect is still controversial. In the present work, we studied the regulative effect of caveolin-1 on the expression of tight junction-associated proteins and BTB via directly silencing and overexpressing of caveolin-1 by recombinant adenovirus transduction of glioma-derived microvascular endothelial cells in rat brain. The results show that the caveolin-1 downregulation resulted in decreased expression of tight junction-associated proteins, opening of tight junctions, and increasing the permeability of BTB, whereas the overexpression of caveolin-1 presented the opposite effects. Therefore, we conclude that caveolin-1 regulates the expression of tight junction-associated proteins in a positive manner, which further plays a role in the regulation of BTB permeability. This finding provides a novel therapeutic target for selectively opening of BTB.

Entities:  

Keywords:  Caveolin-1; ZO-1; blood-tumor barrier; claudin-5; occludin; tight junction-associated proteins

Mesh：

Substances：

Year:  2015        PMID： 26722502      PMCID： PMC4680447     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  38 in total

Review 1.  Caveolins, liquid-ordered domains, and signal transduction.

Authors:  E J Smart; G A Graf; M A McNiven; W C Sessa; J A Engelman; P E Scherer; T Okamoto; M P Lisanti
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

2.  Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity.

Authors:  H Ju; R Zou; V J Venema; R C Venema
Journal:  J Biol Chem       Date:  1997-07-25       Impact factor: 5.157

3.  Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo.

Authors:  G García-Cardeña; P Martasek; B S Masters; P M Skidd; J Couet; S Li; M P Lisanti; W C Sessa
Journal:  J Biol Chem       Date:  1997-10-10       Impact factor: 5.157

4.  The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton.

Authors:  A S Fanning; B J Jameson; L A Jesaitis; J M Anderson
Journal:  J Biol Chem       Date:  1998-11-06       Impact factor: 5.157

5.  Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin.

Authors:  J B Michel; O Feron; D Sacks; T Michel
Journal:  J Biol Chem       Date:  1997-06-20       Impact factor: 5.157

6.  Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins.

Authors:  T Tsukamoto; S K Nigam
Journal:  Am J Physiol       Date:  1999-05

Review 7.  Occludin and claudins in tight-junction strands: leading or supporting players?

Authors:  S Tsukita; M Furuse
Journal:  Trends Cell Biol       Date:  1999-07       Impact factor: 20.808

8.  Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases.

Authors:  S Li; J Couet; M P Lisanti
Journal:  J Biol Chem       Date:  1996-11-15       Impact factor: 5.157

9.  Occludin as a possible determinant of tight junction permeability in endothelial cells.

Authors:  T Hirase; J M Staddon; M Saitou; Y Ando-Akatsuka; M Itoh; M Furuse; K Fujimoto; S Tsukita; L L Rubin
Journal:  J Cell Sci       Date:  1997-07       Impact factor: 5.285

10.  Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

Authors:  M Furuse; M Itoh; T Hirase; A Nagafuchi; S Yonemura; S Tsukita; S Tsukita
Journal:  J Cell Biol       Date:  1994-12       Impact factor: 10.539
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  2 in total

1.  Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.

Authors:  Vanessa Coelho-Santos; Renato Socodato; Camila Portugal; Ricardo A Leitão; Manuel Rito; Marcos Barbosa; Pierre-Olivier Couraud; Ignacio A Romero; Babette Weksler; Richard D Minshall; Carlos Fontes-Ribeiro; Teresa Summavielle; João B Relvas; Ana P Silva
Journal:  Cell Mol Life Sci       Date:  2016-07-04       Impact factor: 9.261

Review 2.  Wnt Signaling in Inner Blood-Retinal Barrier Maintenance.

Authors:  Felix Yemanyi; Kiran Bora; Alexandra K Blomfield; Zhongxiao Wang; Jing Chen
Journal:  Int J Mol Sci       Date:  2021-11-02       Impact factor: 6.208
  2 in total

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