| Literature DB >> 26722444 |
Li-Hua Li1, Bin Lu1, Hong-Ke Wu1, Hao Zhang1, Fei-Fei Yao1.
Abstract
It is well known that the proliferation and migration of ASM cells (ASMCs) plays an important role in the pathogenesis of airway remodeling in asthma. Previous studies reported that apigenin can inhibit airway remodeling in a mouse asthma model. However, its effects on the proliferation and migration of ASMCs in asthma remain unknown. Therefore, the aim of our present study was to investigate the effects of apigenin on ASMC proliferation and migration, and explore the possible molecular mechanism. We found that apigenin inhibited transforming growth factor-β1 (TGF-β1)-induced ASMC proliferation. The cell cycle was blocked at G1/S-interphase by apigenin. It also suppressed TGF-β1-induced ASMCs migration. Furthermore, apigenin inhibited TGF-β1-induced Smad 2 and Smad 3 phosphorylation in ASMCs. Taken together, these results suggested that apigenin inhibited the proliferation and migration of TGF-β1-stimulated ASMCs by inhibiting Smad signaling pathway. These data might provide useful information for treating asthma and show that apigenin has potential for attenuating airway remodeling.Entities:
Keywords: Asthma; airway smooth muscle cells; apigenin; transforming growth factor-β1
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Year: 2015 PMID： 26722444 PMCID： PMC4680389
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625