Literature DB >> 26722413

SASH1 inhibits proliferation and invasion of thyroid cancer cells through PI3K/Akt signaling pathway.

Dawei Sun1, Rui Zhou2, Huamin Liu1, Wenhai Sun1, Anbing Dong1, Hongmei Zhang1.   

Abstract

The SASH1 (SAM- and SH3-domain containing 1) gene, a member of the SLY-family of signal adapter proteins, has an important regulatory role in tumorigenesis, but its implication in thyroid carcinoma has not been yet investigated. In this study, we investigated the role of SASH1 in proliferation and invasion of thyroid cancer cells and the underlying mechanism. Our results demonstrated that SASH1 is down-regulated in thyroid cancer cells. Overexpression of SASH1 inhibits thyroid cancer cell proliferation, migration and invasion with decreased epithelial-mesenchymal transition (EMT). Mechanistically, overexpression of SASH1 inhibits thyroid cancer cell proliferation and invasion through down-regulation of PI3K and Akt phosphorylation. Taken together, the present study showed that the loss or inhibition of SASH1 expression may play an important role in thyroid cancer development, invasion, and metastasis and that SASH1 may be a potential therapeutic target for the treatment of thyroid cancer.

Entities:  

Keywords:  SASH1; invasion; proliferation; thyroid cancer

Mesh：

Substances：

Year:  2015        PMID： 26722413      PMCID： PMC4680358     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  25 in total

1.  Effects of SASH1 on lung cancer cell proliferation, apoptosis, and invasion in vitro.

Authors:  En-guo Chen; Yanfan Chen; Liang-liang Dong; Ji-song Zhang
Journal:  Tumour Biol       Date:  2012-04-10

Review 2.  Epithelial-mesenchymal transitions in development and disease.

Authors:  Jean Paul Thiery; Hervé Acloque; Ruby Y J Huang; M Angela Nieto
Journal:  Cell       Date:  2009-11-25       Impact factor: 41.582

3.  Effects of SASH1 on melanoma cell proliferation and apoptosis in vitro.

Authors:  Sheyu Lin; Junyu Zhang; Jiawei Xu; Honglian Wang; Qing Sang; Qinghe Xing; Lin He
Journal:  Mol Med Rep       Date:  2012-09-26       Impact factor: 2.952

4.  The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.

Authors:  Melanie Martini; Alexandra Gnann; Daniela Scheikl; Bernhard Holzmann; Klaus-Peter Janssen
Journal:  Int J Biochem Cell Biol       Date:  2011-07-28       Impact factor: 5.085

Review 5.  Targeting the PI3K signaling pathway in cancer.

Authors:  Kwok-Kin Wong; Jeffrey A Engelman; Lewis C Cantley
Journal:  Curr Opin Genet Dev       Date:  2009-12-16       Impact factor: 5.578

6.  Overexpression of SASH1 related to the decreased invasion ability of human glioma U251 cells.

Authors:  Liu Yang; Mei Liu; Zhikai Gu; Jianguo Chen; Yaohua Yan; Jian Li
Journal:  Tumour Biol       Date:  2012-08-23

7.  Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus.

Authors:  Armina A Kazi; Kristin Happ Molitoris; Robert D Koos
Journal:  Biol Reprod       Date:  2009-05-06       Impact factor: 4.285

8.  Shikonin inhibits thyroid cancer cell growth and invasiveness through targeting major signaling pathways.

Authors:  Qi Yang; Meiju Ji; Haixia Guan; Bingyin Shi; Peng Hou
Journal:  J Clin Endocrinol Metab       Date:  2013-10-08       Impact factor: 5.958

9.  SASH1 regulates proliferation, apoptosis, and invasion of osteosarcoma cell.

Authors:  Qingbing Meng; Minqian Zheng; Hongbing Liu; Changzhi Song; Wensheng Zhang; Juan Yan; Ling Qin; Xiaolan Liu
Journal:  Mol Cell Biochem       Date:  2012-10-29       Impact factor: 3.396

Review 10.  Progress in molecular-based management of differentiated thyroid cancer.

Authors:  Mingzhao Xing; Bryan R Haugen; Martin Schlumberger
Journal:  Lancet       Date:  2013-03-22       Impact factor: 79.321
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  10 in total

1.  The adaptor SASH1 acts through NOTCH1 and its inhibitor DLK1 in a 3D model of lumenogenesis involving CEACAM1.

Authors:  Kandis Stubblefield; Jennifer Chean; Tung Nguyen; Charng-Jui Chen; John E Shively
Journal:  Exp Cell Res       Date:  2017-08-18       Impact factor: 3.905

2.  SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer.

Authors:  Joshua T Burgess; Emma Bolderson; Jodi M Saunus; Shu-Dong Zhang; Lynne E Reid; Anne Marie McNicol; Sunil R Lakhani; Katharine Cuff; Kerry Richard; Derek J Richard; Kenneth J O'Byrne
Journal:  Oncotarget       Date:  2016-11-08

3.  Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response.

Authors:  Joshua T Burgess; Emma Bolderson; Mark N Adams; Anne-Marie Baird; Shu-Dong Zhang; Kathy A Gately; Kazuo Umezawa; Kenneth J O'Byrne; Derek J Richard
Journal:  Cell Death Dis       Date:  2016-11-10       Impact factor: 8.469

4.  HMGB1 contributes to SASH1 methylation to attenuate astrocyte adhesion.

Authors:  Ronghua Wu; Yingying Yan; Chao Ma; Han Chen; Zhangji Dong; Yongjun Wang; Yan Liu; Mei Liu; Liu Yang
Journal:  Cell Death Dis       Date:  2019-05-28       Impact factor: 8.469

5.  Overexpression of SASH1 Inhibits the Proliferation, Invasion, and EMT in Hepatocarcinoma Cells.

Authors:  Ping He; Hong-Xia Zhang; Chang-Yu Sun; Chun-Yong Chen; He-Qing Jiang
Journal:  Oncol Res       Date:  2016       Impact factor: 5.574

Review 6.  Glycosylation in Cancer: Interplay between Multidrug Resistance and Epithelial-to-Mesenchymal Transition?

Authors:  Leonardo Marques da Fonseca; Vanessa Amil da Silva; Leonardo Freire-de-Lima; José Osvaldo Previato; Lucia Mendonça-Previato; Márcia Alves Marques Capella
Journal:  Front Oncol       Date:  2016-06-22       Impact factor: 6.244

7.  Combretastatin A4 Regulates Proliferation, Migration, Invasion, and Apoptosis of Thyroid Cancer Cells via PI3K/Akt Signaling Pathway.

Authors:  Weixin Liang; Yongqiang Lai; Mingzhang Zhu; Shangshu Huang; Weizhao Feng; Xiaoyu Gu
Journal:  Med Sci Monit       Date:  2016-12-14

8.  SASH1 Suppresses the Proliferation and Invasion of Human Skin Squamous Cell Carcinoma Cells via Inhibiting Akt Cascade.

Authors:  Shang-Zhou Chen; Yang Zhang; Shu-Ying Lei; Fa-Qiong Zhou
Journal:  Onco Targets Ther       Date:  2020-05-25       Impact factor: 4.147

9.  SASH1 is a prognostic indicator and potential therapeutic target in non-small cell lung cancer.

Authors:  Joshua T Burgess; Emma Bolderson; Mark N Adams; Pascal H G Duijf; Shu-Dong Zhang; Steven G Gray; Gavin Wright; Derek J Richard; Kenneth J O'Byrne
Journal:  Sci Rep       Date:  2020-10-29       Impact factor: 4.379

Review 10.  Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis.

Authors:  Amir B Ghaemmaghami; Maryam Mahjoubin-Tehran; Ahmad Movahedpour; Korosh Morshedi; Amirhossein Sheida; Seyed Pouya Taghavi; Hamed Mirzaei; Michael R Hamblin
Journal:  Cell Commun Signal       Date:  2020-08-03       Impact factor: 7.525
  10 in total

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