Na Tang1, Lin Ma2, Xu-Yong Lin1, Yong Zhang1, Da-Lei Yang3, En-Hua Wang1, Xue-Shan Qiu1. 1. Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China. 2. Department of Pathology, Liaoning Tumor Hospital Shenyang 110042, China. 3. Center for Assisted Reproduction, Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University Shenyang 110004, China.
Abstract
BACKGROUND: Recent studies demonstrate that plant homeodomain finger protein 20 (PHF20), which was initially described as an immunogenic antigen in glioblastoma, is a putative transcriptional factor, and exhibits tumor suppressor activity. However, little is known about its expression and clinical significance in lung cancer. METHODS: We investigated the expression of PHF20 in 142 cases of NSCLC tissue and 30 cases of normal lung tissue by immunohistochemical staining and downregulated PHF20 expression in SPC cell. RESULTS: PHF20 expression was significantly higher in normal lung tissues than that in NSCLC tissues. The expression of PHF20 in NSCLC was significantly correlated with histological grade, p-TNM stage and lymph node metastasis. Moreover, the loss of PHF20 expression was associated with short overall survival. We also found that the expression of PHF20 was associated with Bax expression. Additionally, PHF20 markedly inhibited cell proliferation and invasion. CONCLUSIONS: PHF20 may play an important role in NSCLC, and may serve as a potential therapeutic target of NSCLC.
BACKGROUND: Recent studies demonstrate that plant homeodomain finger protein 20 (PHF20), which was initially described as an immunogenic antigen in glioblastoma, is a putative transcriptional factor, and exhibits tumor suppressor activity. However, little is known about its expression and clinical significance in lung cancer. METHODS: We investigated the expression of PHF20 in 142 cases of NSCLC tissue and 30 cases of normal lung tissue by immunohistochemical staining and downregulated PHF20 expression in SPC cell. RESULTS:PHF20 expression was significantly higher in normal lung tissues than that in NSCLC tissues. The expression of PHF20 in NSCLC was significantly correlated with histological grade, p-TNM stage and lymph node metastasis. Moreover, the loss of PHF20 expression was associated with short overall survival. We also found that the expression of PHF20 was associated with Bax expression. Additionally, PHF20 markedly inhibited cell proliferation and invasion. CONCLUSIONS:PHF20 may play an important role in NSCLC, and may serve as a potential therapeutic target of NSCLC.
Authors: M Krajewska; S Krajewski; J I Epstein; A Shabaik; J Sauvageot; K Song; S Kitada; J C Reed Journal: Am J Pathol Date: 1996-05 Impact factor: 4.307
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