Literature DB >> 26722227

Competing endogenous RNA: A novel posttranscriptional regulatory dimension associated with the progression of cancer.

Qingsong Dai1, Jixia Li2, Keyuan Zhou3, Tong Liang3.   

Abstract

The existence of artificial sponges and antisense oligonucleotides designed to decrease the availability of microRNAs (miRNAs), a family of small non-coding RNAs that target RNA transcripts through miRNA response elements (MREs) involved in gene expression, suggests that miRNAs may also be regulated. The wide range of RNA transcripts harboring MREs, termed competing endogenous RNAs (ceRNAs), includes protein-coding messenger RNAs (mRNAs) and non-coding RNAs, for example long non-coding RNAs, pseudogenes and circular RNAs, which compete for a common pool of miRNAs as natural decoys. These ceRNAs are co-regulated and produce large, complex posttranscriptional regulatory networks, which have been implicated in numerous biological processes. The present review discusses recent discoveries that implicate natural microRNA decoys in the development of cancer.

Entities:  

Keywords:  cancer; competing endogenous RNA; microRNA

Year:  2015        PMID： 26722227      PMCID： PMC4665929          DOI： 10.3892/ol.2015.3698

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  65 in total

1.  Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal.

Authors:  Yue Wang; Zhenyu Xu; Junfeng Jiang; Chen Xu; Jiuhong Kang; Lei Xiao; Minjuan Wu; Jun Xiong; Xiaocan Guo; Houqi Liu
Journal:  Dev Cell       Date:  2013-03-28       Impact factor: 12.270

2.  Linc-RNA-RoR acts as a "sponge" against mediation of the differentiation of endometrial cancer stem cells by microRNA-145.

Authors:  Xi Zhou; Qin Gao; Jianzhong Wang; Xin Zhang; Kaige Liu; Zhao Duan
Journal:  Gynecol Oncol       Date:  2014-02-28       Impact factor: 5.482

3.  Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells.

Authors:  Takeshi Chiyomaru; Shinichiro Fukuhara; Sharanjot Saini; Shahana Majid; Guoren Deng; Varahram Shahryari; Inik Chang; Yuichiro Tanaka; Hideki Enokida; Masayuki Nakagawa; Rajvir Dahiya; Soichiro Yamamura
Journal:  J Biol Chem       Date:  2014-03-10       Impact factor: 5.157

Review 4.  MicroRNAs: potential biomarkers for cancer diagnosis, prognosis and targets for therapy.

Authors:  William C S Cho
Journal:  Int J Biochem Cell Biol       Date:  2009-12-22       Impact factor: 5.085

5.  Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.

Authors:  Ugo Ala; Florian A Karreth; Carla Bosia; Andrea Pagnani; Riccardo Taulli; Valentine Léopold; Yvonne Tay; Paolo Provero; Riccardo Zecchina; Pier Paolo Pandolfi
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-27       Impact factor: 11.205

6.  Fibronectin 1 mRNA expression correlates with advanced disease in renal cancer.

Authors:  Sandra Waalkes; Faranaz Atschekzei; Mario W Kramer; Jörg Hennenlotter; Gesa Vetter; Jan U Becker; Arnulf Stenzl; Axel S Merseburger; Andres J Schrader; Markus A Kuczyk; Jürgen Serth
Journal:  BMC Cancer       Date:  2010-09-22       Impact factor: 4.430

7.  HMGA2 participates in transformation in human lung cancer.

Authors:  Francescopaolo Di Cello; Joelle Hillion; Alexandra Hristov; Lisa J Wood; Mita Mukherjee; Andrew Schuldenfrei; Jeanne Kowalski; Raka Bhattacharya; Raheela Ashfaq; Linda M S Resar
Journal:  Mol Cancer Res       Date:  2008-05       Impact factor: 5.852

8.  SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions.

Authors:  Cindy Vandewalle; Joke Comijn; Bram De Craene; Petra Vermassen; Erik Bruyneel; Henriette Andersen; Eugene Tulchinsky; Frans Van Roy; Geert Berx
Journal:  Nucleic Acids Res       Date:  2005-11-24       Impact factor: 16.971

9.  A 3'-untranslated region (3'UTR) induces organ adhesion by regulating miR-199a* functions.

Authors:  Daniel Y Lee; Tatiana Shatseva; Zina Jeyapalan; William W Du; Zhaoqun Deng; Burton B Yang
Journal:  PLoS One       Date:  2009-02-18       Impact factor: 3.240

10.  Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs.

Authors:  Ana C Marques; Jennifer Tan; Sheena Lee; Lesheng Kong; Andreas Heger; Chris P Ponting
Journal:  Genome Biol       Date:  2012-11-15       Impact factor: 13.583
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  12 in total

1.  Biomarker potentials of miRNA-associated circRNAs in breast cancer (MCF-7) cells: an in vitro and in silico study.

Authors:  Sema Misir; Ceylan Hepokur; Yuksel Aliyazicioglu; Francisco J Enguita
Journal:  Mol Biol Rep       Date:  2021-03-28       Impact factor: 2.316

Review 2.  Cervical cancer development, chemoresistance, and therapy: a snapshot of involvement of microRNA.

Authors:  Tandrima Mitra; Selvakumar Elangovan
Journal:  Mol Cell Biochem       Date:  2021-08-28       Impact factor: 3.396

3.  Long non-coding RNA LINC01426 facilitates glioblastoma progression via sponging miR-345-3p and upregulation of VAMP8.

Authors:  Jingwei Cao; Zhanbin Tang; Zhiqiang Su
Journal:  Cancer Cell Int       Date:  2020-07-20       Impact factor: 5.722

Review 4.  microRNAs: New-Age Panacea in Cancer Therapeutics.

Authors:  Neelanjana Sarkar; Arun Kumar
Journal:  Indian J Surg Oncol       Date:  2020-06-06

5.  Small RNAs and the competing endogenous RNA network in high grade serous ovarian cancer tumor spread.

Authors:  Anna Bachmayr-Heyda; Katharina Auer; Nyamdelger Sukhbaatar; Stefanie Aust; Simon Deycmar; Agnes T Reiner; Stephan Polterauer; Sabine Dekan; Dietmar Pils
Journal:  Oncotarget       Date:  2016-06-28

6.  Construction and Comprehensive Analysis for Dysregulated Long Non-Coding RNA (lncRNA)-Associated Competing Endogenous RNA (ceRNA) Network in Gastric Cancer.

Authors:  Fengxi Li; Chuiguo Huang; Qian Li; Xianghua Wu
Journal:  Med Sci Monit       Date:  2018-01-03

7.  Construction and analysis for differentially expressed long non-coding RNAs and MicroRNAs mediated competing endogenous RNA network in colon cancer.

Authors:  Fengxi Li; Qian Li; Xianghua Wu
Journal:  PLoS One       Date:  2018-02-08       Impact factor: 3.240

8.  Comprehensive analysis of aberrantly expressed profiles of lncRNAs and miRNAs with associated ceRNA network in muscle-invasive bladder cancer.

Authors:  Hanbo Wang; Leilei Niu; Shaobo Jiang; Jing Zhai; Ping Wang; Feng Kong; Xunbo Jin
Journal:  Oncotarget       Date:  2016-12-27

9.  MicroRNA-related transcription factor regulatory networks in human colorectal cancer.

Authors:  Shuhong Hao; Sibo Huo; Zhenwu Du; Qiwei Yang; Ming Ren; Shui Liu; Tongjun Liu; Guizhen Zhang
Journal:  Medicine (Baltimore)       Date:  2019-04       Impact factor: 1.817

Review 10.  Elucidating the Role of Host Long Non-Coding RNA during Viral Infection: Challenges and Paths Forward.

Authors:  David J Lemler; Hayden N Brochu; Fang Yang; Erin A Harrell; Xinxia Peng
Journal:  Vaccines (Basel)       Date:  2017-10-20
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