Literature DB >> 26722167

Successful treatment of pegaspargase-induced acute hepatotoxicity with vitamin B complex and L-carnitine.

Gary Lu1, Vinit Karur1, Jon D Herrington1, Mary G Walker1.   

Abstract

Pegaspargase is a chemotherapy drug used in the treatment of acute lymphoblastic leukemia (ALL). One of the adverse effects of pegaspargase is hepatotoxicity, which can rapidly lead to liver failure and death. We report a patient with ALL who developed pegaspargase-induced severe hepatotoxicity that was rescued by treatment with vitamin B complex and L-carnitine. Our patient had a quicker response than prior reported cases, suggesting this treatment might be a better regimen.

Entities:  

Year:  2016        PMID： 26722167      PMCID： PMC4677852          DOI： 10.1080/08998280.2016.11929355

Source DB:  PubMed          Journal:  Proc (Bayl Univ Med Cent)        ISSN： 0899-8280


  6 in total

1.  Treatment of nucleoside reverse transcriptase inhibitor-induced lactic acidosis.

Authors:  K Brinkman; S Vrouenraets; R Kauffmann; H Weigel; J Frissen
Journal:  AIDS       Date:  2000-12-01       Impact factor: 4.177

Review 2.  Treatment of acute lymphoblastic leukemia.

Authors:  Ching-Hon Pui; William E Evans
Journal:  N Engl J Med       Date:  2006-01-12       Impact factor: 91.245

3.  Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors.

Authors:  Chadi Al-Nawakil; Lise Willems; Cedric Mauprivez; Benjamin Laffy; Mona Benm'rad; Jerome Tamburini; Helene Fontaine; Philippe Sogni; Benoit Terris; Didier Bouscary; Laurence Moachon
Journal:  Leuk Lymphoma       Date:  2013-11-14

Review 4.  L-asparaginase.

Authors:  J P Whitecar; G P Bodey; J E Harris; E J Freireich
Journal:  N Engl J Med       Date:  1970-03-26       Impact factor: 91.245

5.  Fatal liver failure in an adult patient with acute lymphoblastic leukemia following treatment with L-asparaginase.

Authors:  Michael Bodmer; Michael Sulz; Sylvia Stadlmann; Armin Droll; Luigi Terracciano; Stephan Krähenbühl
Journal:  Digestion       Date:  2006-09-19       Impact factor: 3.216

6.  Pharmacokinetics-based integration of multiple doses of intravenous pegaspargase in a pediatric regimen for adults with newly diagnosed acute lymphoblastic leukemia.

Authors:  Dan Douer; Ibrahim Aldoss; Matthew A Lunning; Patrick W Burke; Laleh Ramezani; Lisa Mark; Janice Vrona; Jae H Park; Martin S Tallman; Vassilios I Avramis; Vinod Pullarkat; Ann M Mohrbacher
Journal:  J Clin Oncol       Date:  2014-02-10       Impact factor: 44.544
  6 in total
  5 in total

1.  L-carnitine does not ameliorate asparaginase-associated hepatotoxicity in a C57BL6 mouse model.

Authors:  Yiwei Liu; Laura J Janke; Lie Li; Mary V Relling
Journal:  Leuk Lymphoma       Date:  2019-02-04

Review 2.  Asparaginase in the Treatment of Acute Lymphoblastic Leukemia in Adults: Current Evidence and Place in Therapy.

Authors:  Krishna R Juluri; Chloe Siu; Ryan D Cassaday
Journal:  Blood Lymphat Cancer       Date:  2022-05-30

3.  L-carnitine and Vitamin B Complex for PEG-L-asparaginase-Induced Hepatotoxicity.

Authors:  Sumant Arora; Jagpal Klair; Andrew M Bellizzi; Tomohiro Tanaka
Journal:  ACG Case Rep J       Date:  2019-08-28

4.  Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice.

Authors:  Gundala Venkata Naveen Kumar; Keito Hoshitsuki; Sanjay Rathod; Manda J Ramsey; Lauren Kokai; Erin E Kershaw; Wen Xie; Christian A Fernandez
Journal:  Acta Pharm Sin B       Date:  2021-12-04       Impact factor: 11.413

5.  Levocarnitine for pegaspargase-induced hepatotoxicity in older children and young adults with acute lymphoblastic leukemia.

Authors:  Rachael Schulte; Ashley Hinson; Van Huynh; Erin H Breese; Joanna Pierro; Seth Rotz; Benjamin A Mixon; Jennifer L McNeer; Michael J Burke; Etan Orgel
Journal:  Cancer Med       Date:  2021-09-16       Impact factor: 4.452
  5 in total

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