Olaguoke Akinwande1, Prejesh Philips2, Charles Scoggins2, Robert C G Martin3. 1. Department of Radiology, Division of Interventional Radiology, Johns Hopkins University, Baltimore, MD, U.S.A. 2. Department of Surgical Oncology, University of Louisville, Louisville, KY, U.S.A. 3. Department of Surgical Oncology, University of Louisville, Louisville, KY, U.S.A. Robert.Martin@louisville.edu.
Abstract
BACKGROUND/AIM: Hepatocellular cancer is a rising dilemma. Patients with unresectable disease may benefit from locoregional therapy. The comparative effectiveness of radioembolization and Doxorubicin-Drug-Eluting-Beads (DEBDOX) has not been established to date. We compared the performance of radioembolization and DEBDOX in the treatment of hepatocellular carcinoma. PATIENTS AND METHODS: An analysis of our prospectively managed locoregional therapy (LRT) database was performed. Three hundred and fifty-eight patients were treated with LRT for unresectable HCC, out of which 291 were treated with DEBDOX and 67 with Ytrrium-90 ((90)Y). Comparative toxicity, tumor response, progression-free survival (PFS) and overall survival (OS) were assessed. Propensity score matching was used to reduce treatment-selection bias, producing 48 pairs. Comparative analysis was repeated after propensity matching. RESULTS: Median age was 67 and 65 years for the DEBDOX and (90)Y groups respectively (p=0.2). Overall survival favored the DEBDOX group (DEBDOX: 15-months, (90)Y: 6-months, p<0.0001). PFS also favored the DEBDOX group (DEBDOX: 15-months, (90)Y: 6-months, p<0.0001). All-grade adverse events were similar in both groups, although slightly favoring the DEBDOX group (DEBDOX 10%, (90)Y 15%, p=0.1). After propensity score matching, again longer OS was seen with the DEBDOX group (DEBDOX 13 months, (90)Y 4 months; p=0.0077). There were also similar all-grade adverse events that slightly favored DEBDOX (DEBDOX 14%, (90)Y 20%, p=0.3). Disease control rate was found to be statistically significant, favoring the DEBDOX group (DEBDOX 72%, (90)Y 48%; p=0.02). CONCLUSION: Our observation suggests that DEBDOX outperforms (90)Y with superior efficacy and survival with a trend towards lower all-grade toxicity. Copyright
BACKGROUND/AIM: Hepatocellular cancer is a rising dilemma. Patients with unresectable disease may benefit from locoregional therapy. The comparative effectiveness of radioembolization and Doxorubicin-Drug-Eluting-Beads (DEBDOX) has not been established to date. We compared the performance of radioembolization and DEBDOX in the treatment of hepatocellular carcinoma. PATIENTS AND METHODS: An analysis of our prospectively managed locoregional therapy (LRT) database was performed. Three hundred and fifty-eight patients were treated with LRT for unresectable HCC, out of which 291 were treated with DEBDOX and 67 with Ytrrium-90 ((90)Y). Comparative toxicity, tumor response, progression-free survival (PFS) and overall survival (OS) were assessed. Propensity score matching was used to reduce treatment-selection bias, producing 48 pairs. Comparative analysis was repeated after propensity matching. RESULTS: Median age was 67 and 65 years for the DEBDOX and (90)Y groups respectively (p=0.2). Overall survival favored the DEBDOX group (DEBDOX: 15-months, (90)Y: 6-months, p<0.0001). PFS also favored the DEBDOX group (DEBDOX: 15-months, (90)Y: 6-months, p<0.0001). All-grade adverse events were similar in both groups, although slightly favoring the DEBDOX group (DEBDOX 10%, (90)Y 15%, p=0.1). After propensity score matching, again longer OS was seen with the DEBDOX group (DEBDOX 13 months, (90)Y 4 months; p=0.0077). There were also similar all-grade adverse events that slightly favored DEBDOX (DEBDOX 14%, (90)Y 20%, p=0.3). Disease control rate was found to be statistically significant, favoring the DEBDOX group (DEBDOX 72%, (90)Y 48%; p=0.02). CONCLUSION: Our observation suggests that DEBDOX outperforms (90)Y with superior efficacy and survival with a trend towards lower all-grade toxicity. Copyright
Authors: B M Meyers; J Knox; R Cosby; J R Beecroft; K K W Chan; N Coburn; J Feld; D Jonker; A Mahmud; J Ringash Journal: Curr Oncol Date: 2020-05-01 Impact factor: 3.677
Authors: Minseok Albert Kim; Heejoon Jang; Na Ryung Choi; Joon Yeul Nam; Yun Bin Lee; Eun Ju Cho; Jeong-Hoon Lee; Su Jong Yu; Hyo-Cheol Kim; Jin Wook Chung; Jung-Hwan Yoon; Yoon Jun Kim Journal: J Hepatocell Carcinoma Date: 2021-12-07