Ewa Poleszak1, Aleksandra Szopa2, Elżbieta Wyska3, Wirginia Kukuła-Koch4, Anna Serefko2, Sylwia Wośko2, Karolina Bogatko2, Andrzej Wróbel5, Piotr Wlaź6. 1. Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland. Electronic address: ewa.poleszak@umlub.pl. 2. Department of Applied Pharmacy, Medical University of Lublin, Lublin, Poland. 3. Department of Pharmacokinetics and Physical Pharmacy, Collegium Medicum, Jagiellonian University, Kraków, Poland. 4. Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Lublin, Poland. 5. Second Department of Gynecology, Medical University of Lublin, Lublin, Poland. 6. Department of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland.
Abstract
BACKGROUND: The main goal of this research was an evaluation of the influence of caffeine on the activity of mianserin and agomelatine. METHODS: The mouse forced swim test and tail suspension test were used to determine the influence of caffeine on the activity of the tested drugs. Drug concentrations in serum and brains were estimated by HPLC. RESULTS: Caffeine increases the anti-immobility action of mianserin and agomelatine. The observed effects were not associated with changes in the level of drugs in serum or brains. CONCLUSION: The synergistic effect of caffeine and the tested drugs may be associated with their summative actions on monoaminergic neurotransmission. Caffeine-mianserin and caffeine-agomelatine interactions might have been of pharmacodynamic origin.
BACKGROUND: The main goal of this research was an evaluation of the influence of caffeine on the activity of mianserin and agomelatine. METHODS: The mouse forced swim test and tail suspension test were used to determine the influence of caffeine on the activity of the tested drugs. Drug concentrations in serum and brains were estimated by HPLC. RESULTS: Caffeine increases the anti-immobility action of mianserin and agomelatine. The observed effects were not associated with changes in the level of drugs in serum or brains. CONCLUSION: The synergistic effect of caffeine and the tested drugs may be associated with their summative actions on monoaminergic neurotransmission. Caffeine-mianserin and caffeine-agomelatine interactions might have been of pharmacodynamic origin.
Authors: David J Hinton; Lindsey G Andres-Beck; Kelle E Nett; Alfredo Oliveros; Sun Choi; Marin Veldic; Doo-Sup Choi Journal: Behav Brain Res Date: 2019-05-13 Impact factor: 3.332
Authors: Aleksandra Szopa; Ewa Poleszak; Urszula Doboszewska; Mariola Herbet; Katarzyna Świąder; Elżbieta Wyska; Anna Serefko; Aleksandra Wlaź; Agnieszka Korga; Marta Ostrowska; Piotr Juś; Szymon Jedynak; Jarosław Dudka; Piotr Wlaź Journal: Psychopharmacology (Berl) Date: 2018-06-07 Impact factor: 4.530