| Literature DB >> 26719157 |
Kyueng-Whan Min1, Dong-Hoon Kim2, Sung-Im Do3, Seoung Wan Chae3, Kyungeun Kim3, Jin Hee Sohn3, Jung-Soo Pyo3, Hyun Joo Lee3, Dong Hyun Kim3, Sukjoong Oh4, Seon Hyeong Choi5, Yong Lai Park6, Chan Heun Park6, Eun-Kyung Kim7, Mi Jung Kwon1, Jinwon Seo1, Kyoung Min Moon8.
Abstract
GATA3 and fascin proteins are known prognostic markers in several cancers. GATA3 is a key regulator of mammary gland morphogenesis and luminal cell differentiation, whereas fascin is a pro-metastatic actin-bundling protein. In this study, we analyzed and compared the predictive abilities of GATA3 and fascin for clinical outcomes of patients with breast cancer. The combined expression pattern based on GATA3-/+ and fascin-/+ was evaluated by immunostaining using a tissue microarray, and relationships between protein expression and several clinicopathological parameters were analyzed. GATA3 expression was associated with good prognostic parameters, but fascin was correlated with poor prognostic parameters. On comparing GATA3 and fascin, we found an inverse relationship between fascin and GATA3 expressions. On analysis of combined markers, GATA3+/fascin- was correlated with improved clinical outcomes compared to GATA3-/fascin+. Univariate and multivariate analyses revealed significant differences in relapse-free and overall survival between GATA3+/fascin- and GATA3-/fascin+. Combined marker analysis of GATA3/fascin showed an inverse association and improved prognostic information for patients with breast cancer.Entities:
Keywords: Breast cancer; Fascin protein; GATA3 protein; Prognosis
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Year: 2015 PMID： 26719157 DOI： 10.1007/s00428-015-1894-5
Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064