Davy Vancampfort1, Simon Rosenbaum2, Felipe B Schuch3, Philip B Ward2, Michel Probst4, Brendon Stubbs5. 1. KU Leuven-University of Leuven Department of Rehabilitation Sciences, Tervuursevest 101, Leuven, Belgium; KU Leuven-University of Leuven, Z.org Leuven, campus Kortenberg, Leuvensesteenweg 517, Kortenberg, Belgium. Electronic address: Davy.Vancampfort@uc-kortenberg.be. 2. School of Psychiatry, University of New South Wales, Liverpool NSW 2170, Sydney, Australia. 3. Hospital de Clinicas de Porto Alegre, R. Ramiro Barcelos, 2350-Santa Cecilia, Porto Alegre, Brazil; Programa de Pós Graduação em Ciências Médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 4. KU Leuven-University of Leuven Department of Rehabilitation Sciences, Tervuursevest 101, Leuven, Belgium. 5. Physiotherapy Department, South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, United Kingdom; Health Service and Population Research Department, Institute of Psychiatry, King's College London, De Crespigny Park, London, Box SE5 8AF, United Kingdom.
Abstract
OBJECTIVE: Physical activity interventions have been shown to improve the health of people with schizophrenia, yet treatment dropout poses an important challenge in this population, and rates vary substantially across studies. We conducted a meta-analysis to investigate the prevalence and predictors of treatment dropout in physical activity interventions in people with schizophrenia. METHOD: We systematically searched major electronic databases from inception until August 2015. Randomized controlled trials of physical activity interventions in people with schizophrenia reporting dropout rates were included. Two independent authors conducted searches and extracted data. Random-effects meta-analysis and meta-regression analyses were conducted. RESULTS: In 19 studies, 594 patients with schizophrenia assigned to exercise interventions were investigated (age=37.2 years, 67.5% male, range=37.5%-100%). Trim and fill adjusted treatment dropout rate was 26.7% [95% confidence interval (CI)=19.7%-35.0%], which is more than double than in nonactive control interventions (odds ratio=2.15, 95% CI=1.29-3.58, P=.003). In the multivariate regression, qualification of the professional delivering the intervention (β=-1.06, 95% CI=-1.77 to -0.35, P=.003) moderated treatment dropout rates, while continuous supervision of physical activity approached statistical significance (P=.05). CONCLUSIONS: Qualified professionals (e.g., physical therapists/exercise physiologists) should prescribe supervised physical activity for people with schizophrenia to enhance adherence, improve psychiatric symptoms and reduce the onset and burden of cardiovascular disease.
OBJECTIVE: Physical activity interventions have been shown to improve the health of people with schizophrenia, yet treatment dropout poses an important challenge in this population, and rates vary substantially across studies. We conducted a meta-analysis to investigate the prevalence and predictors of treatment dropout in physical activity interventions in people with schizophrenia. METHOD: We systematically searched major electronic databases from inception until August 2015. Randomized controlled trials of physical activity interventions in people with schizophrenia reporting dropout rates were included. Two independent authors conducted searches and extracted data. Random-effects meta-analysis and meta-regression analyses were conducted. RESULTS: In 19 studies, 594 patients with schizophrenia assigned to exercise interventions were investigated (age=37.2 years, 67.5% male, range=37.5%-100%). Trim and fill adjusted treatment dropout rate was 26.7% [95% confidence interval (CI)=19.7%-35.0%], which is more than double than in nonactive control interventions (odds ratio=2.15, 95% CI=1.29-3.58, P=.003). In the multivariate regression, qualification of the professional delivering the intervention (β=-1.06, 95% CI=-1.77 to -0.35, P=.003) moderated treatment dropout rates, while continuous supervision of physical activity approached statistical significance (P=.05). CONCLUSIONS: Qualified professionals (e.g., physical therapists/exercise physiologists) should prescribe supervised physical activity for people with schizophrenia to enhance adherence, improve psychiatric symptoms and reduce the onset and burden of cardiovascular disease.
Authors: Davy Vancampfort; Joseph Firth; Felipe B Schuch; Simon Rosenbaum; James Mugisha; Mats Hallgren; Michel Probst; Philip B Ward; Fiona Gaughran; Marc De Hert; André F Carvalho; Brendon Stubbs Journal: World Psychiatry Date: 2017-10 Impact factor: 49.548
Authors: John A Naslund; Kelly A Aschbrenner; Sarah I Pratt; Matthew C Lohman; Emily A Scherer; Gregory J McHugo; Lisa A Marsch; Jürgen Unützer; Stephen J Bartels Journal: J Nerv Ment Dis Date: 2017-08 Impact factor: 2.254
Authors: Garcia Ashdown-Franks; Joseph Firth; Rebekah Carney; Andre F Carvalho; Mats Hallgren; Ai Koyanagi; Simon Rosenbaum; Felipe B Schuch; Lee Smith; Marco Solmi; Davy Vancampfort; Brendon Stubbs Journal: Sports Med Date: 2020-01 Impact factor: 11.136