Tsugumasa Kamata1, Kuniko Sunami2, Akihiko Yoshida3, Kouya Shiraishi4, Koh Furuta5, Yoko Shimada4, Hitoshi Katai6, Shun-Ichi Watanabe7, Hisao Asamura8, Takashi Kohno4, Koji Tsuta9. 1. Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan; Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan; Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan. 2. Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan. 3. Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan. 4. Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan. 5. Division of Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan. 6. Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Tokyo, Japan; Division of Gastric Surgery, National Cancer Center Hospital, Tokyo, Japan. 7. Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan. 8. Department of Surgery, Division of General Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan. 9. Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan; Department of Pathology and Laboratory Medicine, Kansai Medical University, Osaka, Japan. Electronic address: tsutakoj@hirakata.kmu.ac.jp.
Abstract
INTRODUCTION: Ciliated muconodular papillary tumors (CMPTs) are recently characterized, rare peripheral nodules of the lung. These small tumors are histologically comprised of a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, and consistently follow a benign clinical course. However, the histogenesis of CMPTs remains uncertain. METHODS: We performed detailed genomic analyses of 10 archived CMPT cases, using next-generation sequencing and high-resolution melting analysis. RESULTS: Mutations were identified in eight of the 10 cases (80%); four cases harbored the BRAF-V600E mutation, one case harbored the BRAF-G606R mutation, and three cases harbored deletions in exon 19 of EGFR. All of the deletions in EGFR were of the E746-T751/S752V subtype. CONCLUSIONS: The high prevalence of driver gene mutations in CMPTs supports the notion that these lesions are neoplastic rather than reactive or metaplastic.
INTRODUCTION:Ciliated muconodular papillary tumors (CMPTs) are recently characterized, rare peripheral nodules of the lung. These small tumors are histologically comprised of a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, and consistently follow a benign clinical course. However, the histogenesis of CMPTs remains uncertain. METHODS: We performed detailed genomic analyses of 10 archived CMPT cases, using next-generation sequencing and high-resolution melting analysis. RESULTS: Mutations were identified in eight of the 10 cases (80%); four cases harbored the BRAF-V600E mutation, one case harbored the BRAF-G606R mutation, and three cases harbored deletions in exon 19 of EGFR. All of the deletions in EGFR were of the E746-T751/S752V subtype. CONCLUSIONS: The high prevalence of driver gene mutations in CMPTs supports the notion that these lesions are neoplastic rather than reactive or metaplastic.
Authors: Jason C Chang; Joseph Montecalvo; Laetitia Borsu; Shaohua Lu; Brandon T Larsen; William Dean Wallace; Wichit Sae-Ow; Alexander C Mackinnon; Hyunjae R Kim; Anita Bowman; Jennifer L Sauter; Maria E Arcila; Marc Ladanyi; William D Travis; Natasha Rekhtman Journal: Am J Surg Pathol Date: 2018-08 Impact factor: 6.394
Authors: Lucia Kim; Young Sam Kim; Jin Soo Lee; Suk Jin Choi; In Suh Park; Jee Young Han; Joon Mee Kim; Young Chae Chu Journal: J Thorac Dis Date: 2017-12 Impact factor: 2.895