| Literature DB >> 26718830 |
Junxiong Ma1, Jun Liu1, Hailong Yu1, Yu Chen1, Qi Wang1, Liangbi Xiang2.
Abstract
Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a possibility. Diabetes was established by a single injection of streptozotocin at 50 mg/kg in rats. After sciatic nerve crush injury, the diabetic rats were intraperitoneally administrated daily for 4 weeks with metformin (30, 200 and 500 mg/kg), or normal saline, respectively. The axonal regeneration was investigated by morphometric analysis and retrograde labeling. The functional recovery was evaluated by electrophysiological studies and behavioral analysis. It was found that metformin significantly enhanced axonal regeneration and functional recovery compared to saline after sciatic nerve injury in diabetic rats. In addition, metformin at 200 and 500 mg/kg showed better performance than that at 30 mg/kg. Taken together, metformin is capable of promoting nerve regeneration after sciatic nerve injuries in diabetes mellitus, highlighting its therapeutic values for peripheral nerve injury repair in diabetes mellitus.Entities:
Keywords: Functional recovery; Metformin; Nerve regeneration; Neuroprotective; Sciatic nerve injury
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Year: 2015 PMID： 26718830 DOI： 10.1007/s11064-015-1803-y
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996