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Literature DB >> 26718723

Epicardium-derived fibroblasts in heart development and disease.

Ming Fang¹, Fu-Li Xiang¹, Caitlin M Braitsch¹, Katherine E Yutzey².

Abstract

The majority of cardiac fibroblasts in a mature mammalian heart are derived from the epicardium during prenatal development and reactivate developmental programs during the progression of fibrotic disease. In addition, epicardial activation, proliferation, and fibrosis occur with ischemic, but not hypertensive injury. Here we review cellular and molecular mechanisms that control epicardium-derived cell lineages during development and disease with a focus on cardiac fibroblasts. This article is part of a special issue entitled "Fibrosis and Myocardial Remodeling".

Entities: Chemical Disease Gene Species

Keywords: Cardiac fibrosis; Epicardium; Fibroblast lineage; Myocardial infarction

Mesh：

Year: 2015 PMID： 26718723 PMCID： PMC4764446 DOI： 10.1016/j.yjmcc.2015.12.019

Source DB: PubMed Journal: J Mol Cell Cardiol ISSN： 0022-2828 Impact factor: 5.000

50 in total

1. Epicardial spindle orientation controls cell entry into the myocardium.

Authors: Mingfu Wu; Christopher L Smith; James A Hall; Ivy Lee; Kate Luby-Phelps; Michelle D Tallquist
Journal: Dev Cell Date: 2010-07-20 Impact factor: 12.270

2. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.

Authors: Bin Zhou; Qing Ma; Satish Rajagopal; Sean M Wu; Ibrahim Domian; José Rivera-Feliciano; Dawei Jiang; Alexander von Gise; Sadakatsu Ikeda; Kenneth R Chien; William T Pu
Journal: Nature Date: 2008-06-22 Impact factor: 49.962

3. A myocardial lineage derives from Tbx18 epicardial cells.

Authors: Chen-Leng Cai; Jody C Martin; Yunfu Sun; Li Cui; Lianchun Wang; Kunfu Ouyang; Lei Yang; Lei Bu; Xingqun Liang; Xiaoxue Zhang; William B Stallcup; Christopher P Denton; Andrew McCulloch; Ju Chen; Sylvia M Evans
Journal: Nature Date: 2008-05-14 Impact factor: 49.962

4. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.

Authors: Ofelia M Martínez-Estrada; Laura A Lettice; Abdelkader Essafi; Juan Antonio Guadix; Joan Slight; Víctor Velecela; Emma Hall; Judith Reichmann; Paul S Devenney; Peter Hohenstein; Naoki Hosen; Robert E Hill; Ramón Muñoz-Chapuli; Nicholas D Hastie
Journal: Nat Genet Date: 2009-12-20 Impact factor: 38.330

Review 5. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure.

Authors: R Dale Brown; S Kelly Ambler; M Darren Mitchell; Carlin S Long
Journal: Annu Rev Pharmacol Toxicol Date: 2005 Impact factor: 13.820

6. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.

Authors: Alexandra Lepilina; Ashley N Coon; Kazu Kikuchi; Jennifer E Holdway; Richard W Roberts; C Geoffrey Burns; Kenneth D Poss
Journal: Cell Date: 2006-11-03 Impact factor: 41.582

7. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats.

Authors: Fumitaka Kuwahara; Hisashi Kai; Keisuke Tokuda; Mamiko Kai; Akira Takeshita; Kensuke Egashira; Tsutomu Imaizumi
Journal: Circulation Date: 2002-07-02 Impact factor: 29.690

8. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.

Authors: Elisabeth M Zeisberg; Oleg Tarnavski; Michael Zeisberg; Adam L Dorfman; Julie R McMullen; Erika Gustafsson; Anil Chandraker; Xueli Yuan; William T Pu; Anita B Roberts; Eric G Neilson; Mohamed H Sayegh; Seigo Izumo; Raghu Kalluri
Journal: Nat Med Date: 2007-07-29 Impact factor: 53.440

Review 9. Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.

Authors: Heleen Lie-Venema; Nynke M S van den Akker; Noortje A M Bax; Elizabeth M Winter; Saskia Maas; Tuija Kekarainen; Rob C Hoeben; Marco C deRuiter; Robert E Poelmann; Adriana C Gittenberger-de Groot
Journal: ScientificWorldJournal Date: 2007-11-12

10. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.

Authors: Nicola Smart; Catherine A Risebro; Athalie A D Melville; Kelvin Moses; Robert J Schwartz; Kenneth R Chien; Paul R Riley
Journal: Nature Date: 2006-11-15 Impact factor: 49.962

16 in total

Review 1. The epicardium as a hub for heart regeneration.

Authors: Jingli Cao; Kenneth D Poss
Journal: Nat Rev Cardiol Date: 2018-10 Impact factor: 32.419

2. Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium.

Authors: Suresh K Verma; Venkata N S Garikipati; Prasanna Krishnamurthy; Sarah M Schumacher; Laurel A Grisanti; Maria Cimini; Zhongjian Cheng; Mohsin Khan; Yujia Yue; Cindy Benedict; May M Truongcao; Joseph E Rabinowitz; David A Goukassian; Douglas Tilley; Walter J Koch; Raj Kishore
Journal: Circulation Date: 2017-06-30 Impact factor: 29.690

Epicardium-derived fibroblasts in heart development and disease.

1. Epicardial spindle orientation controls cell entry into the myocardium.

2. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.

3. A myocardial lineage derives from Tbx18 epicardial cells.

4. Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin.

Review 5. The cardiac fibroblast: therapeutic target in myocardial remodeling and failure.

6. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.

7. Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats.

8. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.

Review 9. Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.

10. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.

Review 1. The epicardium as a hub for heart regeneration.

2. Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium.

Review 3. Embryonic Chicken (Gallus gallus domesticus) as a Model of Cardiac Biology and Development.

Review 4. Role of carotenoids and retinoids during heart development.

Review 5. Transcriptional control of cardiac fibroblast plasticity.

6. Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.

Review 7. Recent insights on the role and regulation of retinoic acid signaling during epicardial development.

8. Upregulation of Wilms' Tumor 1 in epicardial cells increases cardiac fibrosis in dystrophic mice.

9. Regenerative cross talk between cardiac cells and macrophages.

Review 10. Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?