| Literature DB >> 26718676 |
Stuart J Pocock1, Tim C Clayton2, Gregg W Stone3.
Abstract
As a sequel to last week's paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials, the value of factorial designs, the importance and challenges of strategy trials, Data Monitoring Committees (including when to stop a trial early), and the role of adaptive designs. All topics are illustrated by relevant examples from cardiology trials.Keywords: Data Monitoring Committees; adaptive designs; factorial designs; noninferiority trials; randomized controlled trials as topic; statistical stopping guidelines; strategy trials
Mesh：
Year: 2015 PMID： 26718676 DOI： 10.1016/j.jacc.2015.10.051
Source DB: PubMed Journal: J Am Coll Cardiol ISSN： 0735-1097 Impact factor: 24.094