| Literature DB >> 26718334 |
Marco Colizzi1, Elena Carra1, Sara Fraietta1, John Lally1, Diego Quattrone1, Stefania Bonaccorso1, Valeria Mondelli2, Olesya Ajnakina2, Paola Dazzan1, Antonella Trotta1, Lucia Sideli1, Anna Kolliakou3, Fiona Gaughran1, Mizanur Khondoker4, Anthony S David1, Robin M Murray1, James H MacCabe1, Marta Di Forti5.
Abstract
Both substance use and poor medication adherence are associated with poor outcome in psychosis. To clarify the contributions of substance use and poor medication adherence to poor outcome in the year following a first episode of psychosis, 205 patients were evaluated for use of tobacco, alcohol, cannabis and stimulants at their psychosis onset, and in a 1-year follow-up. Data on medication adherence and symptom remission were also collected. Patients had high rates of overall substance use before (37-65%) and after psychosis onset (45-66%). 44% showed poor medication adherence and 55% did not reach remission from psychosis. Nicotine dependence and cannabis use after psychosis onset significantly predicted both poor medication adherence and non-remission, and poor medication adherence mediated the effects of these substances on non-remission. In conclusion, medication adherence lies on the causal pathway between nicotine dependence and cannabis on the one hand and non-remission on the other.Entities:
Keywords: Cannabis use; First episode psychosis; Medication adherence; Nicotine dependence; Remission; Substance use
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Year: 2015 PMID： 26718334 DOI： 10.1016/j.schres.2015.11.016
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939