| Literature DB >> 2671814 |
B T Hyman1, G W Van Hoesen, K Beyreuther, C L Masters.
Abstract
Neurofibrillary tangles and neuritic plaques are the neuropathological hallmarks of Alzheimer's disease. The latter consist of a core of A4 amyloid protein. We now report that some neurofibrillary tangles ('tombstone tangles') are also A4 immunoreactive. This observation is consistent with the hypothesis that A4 amyloid accumulation is a component of both neurofibrillary tangles and neuritic plaques.Entities:
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Year: 1989 PMID： 2671814 DOI： 10.1016/0304-3940(89)90559-4
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046