Literature DB >> 26717993

The complex role of SIRT6 in carcinogenesis.

Batia Lerrer1, Asaf A Gertler1, Haim Y Cohen2.   

Abstract

SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD(+)-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the implication of SIRT6 in the biology of cancer and the relevance to organism homeostasis and lifespan.
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Year:  2015        PMID： 26717993     DOI： 10.1093/carcin/bgv167

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  39 in total

1.  SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells.

Authors:  Giovanna Sociali; Alessia Grozio; Irene Caffa; Susanne Schuster; Pamela Becherini; Patrizia Damonte; Laura Sturla; Chiara Fresia; Mario Passalacqua; Francesca Mazzola; Nadia Raffaelli; Antje Garten; Wieland Kiess; Michele Cea; Alessio Nencioni; Santina Bruzzone
Journal:  FASEB J       Date:  2018-12-04       Impact factor: 5.191

2.  MicroRNA-351-5p aggravates intestinal ischaemia/reperfusion injury through the targeting of MAPK13 and Sirtuin-6.

Authors:  Yupeng Hu; Xufeng Tao; Xu Han; Lina Xu; Lianhong Yin; Huijun Sun; Yan Qi; Youwei Xu; Jinyong Peng
Journal:  Br J Pharmacol       Date:  2018-07-26       Impact factor: 8.739

Review 3.  SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.

Authors:  Nunzia D'Onofrio; Luigi Servillo; Maria Luisa Balestrieri
Journal:  Antioxid Redox Signal       Date:  2017-06-29       Impact factor: 8.401

4.  The role of SIRT6 in tumors.

Authors:  Vanessa Desantis; Aurelia Lamanuzzi; Angelo Vacca
Journal:  Haematologica       Date:  2018-01       Impact factor: 9.941

5.  Downregulation of SIRT6 is associated with poor prognosis in patients with non-small cell lung cancer.

Authors:  Bojin Zhu; Yongjin Yan; Boyun Shao; Luwen Tian; Weihua Zhou
Journal:  J Int Med Res       Date:  2018-01-24       Impact factor: 1.671

Review 6.  Sirtuins in Renal Health and Disease.

Authors:  Marina Morigi; Luca Perico; Ariela Benigni
Journal:  J Am Soc Nephrol       Date:  2018-04-30       Impact factor: 10.121

7.  miR-34a inhibits tumorigenesis of NSCLC via targeting SIRT6.

Authors:  Libo Ruan; Jun Chen; Litao Ruan; Anjun Tan; Ping Wang
Journal:  Int J Clin Exp Pathol       Date:  2018-03-01

Review 8.  SIRT6: Novel Mechanisms and Links to Aging and Disease.

Authors:  Luisa Tasselli; Wei Zheng; Katrin F Chua
Journal:  Trends Endocrinol Metab       Date:  2016-11-09       Impact factor: 12.015

9.  MiR-125b attenuates human hepatocellular carcinoma malignancy through targeting SIRT6.

Authors:  Shi Song; Yuxia Yang; Minghui Liu; Boya Liu; Xin Yang; Miao Yu; Hao Qi; Mengmeng Ren; Zhe Wang; Junhua Zou; Feng Li; Xiaojuan Du; Hongquan Zhang; Jianyuan Luo
Journal:  Am J Cancer Res       Date:  2018-06-01       Impact factor: 6.166

10.  Aberrant SIRT6 expression contributes to melanoma growth: Role of the autophagy paradox and IGF-AKT signaling.

Authors:  Liwen Wang; Weinan Guo; Jinyuan Ma; Wei Dai; Lin Liu; Sen Guo; Jiaxi Chen; Huina Wang; Yuqi Yang; Xiuli Yi; Gang Wang; Tianwen Gao; Guannan Zhu; Chunying Li
Journal:  Autophagy       Date:  2017-12-31       Impact factor: 16.016
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