The first total synthesis of (±)-gelsenicine is reported. The synthetic route is highly efficient (13 steps), featuring (1) a pivotal metal-catalyzed isomerization/rearrangement process that forges the central core of the molecule and (2) two facile C-N bond-forming steps that establish the flanking heterocycles.
The first total synthesis of (±)-gelsenicine is reported. The synthetic route is highly efficient (13 steps), featuring (1) a pivotal n class="Chemical">metal-catalyzed isomerization/rearrangement process that forges the central core of the molecule and (2) two facile C-N bond-forming steps that establish the flanking heterocycles.
Authors: Ke Kong; John A Enquist; Monica E McCallum; Genessa M Smith; Takanori Matsumaru; Elnaz Menhaji-Klotz; John L Wood Journal: J Am Chem Soc Date: 2013-07-18 Impact factor: 15.419