Literature DB >> 26716076

ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target.

Younggeon Jin1, Anthony T Blikslager1.   

Abstract

The ClC-2 chloride channel is a member of the voltage-gated chloride channel family. ClC-2 is involved in various physiological processes, including fluid transport and secretion, regulation of cell volume and pH, maintaining the membrane potential of the cell, cell-to-cell communication, and tissue homeostasis. Recently, our laboratory has accumulated evidence indicating a critical role of ClC-2 in the regulation of intestinal barrier function by altering inter-epithelial tight junction composition. This review will detail the role of ClC-2 in intestinal barrier function during intestinal disorders, including experimental ischemia/reperfusion injury and dextran sodium sulfate (DSS)-induced inflammatory bowel disease. Details of pharmacological manipulation of ClC-2 via prostone agonists will also be provided in an effort to show the potential therapeutic relevance of ClC-2 regulation, particularly during intestinal barrier disruption.

Entities:  

Keywords:  ClC-2 chloride channel; gastrointestinal diseases; intestinal barrier function; lubiprostone; tight junctions

Year:  2015        PMID： 26716076      PMCID： PMC4681285          DOI： 10.1080/21688370.2015.1105906

Source DB:  PubMed          Journal:  Tissue Barriers        ISSN： 2168-8362


  125 in total

1.  Comparative tight junction protein expressions in colonic Crohn's disease, ulcerative colitis, and tuberculosis: a new perspective.

Authors:  Prasenjit Das; Pooja Goswami; Tapash K Das; Tapas Nag; Vishnubhatla Sreenivas; Vineet Ahuja; Subrat K Panda; Siddhartha Datta Gupta; Govind K Makharia
Journal:  Virchows Arch       Date:  2012-03       Impact factor: 4.064

2.  Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin.

Authors:  Prashant K Nighot; Anthony T Blikslager
Journal:  Am J Physiol Cell Physiol       Date:  2011-09-28       Impact factor: 4.249

3.  Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease.

Authors:  Stephanie A Blair; Sunanda V Kane; Daniel R Clayburgh; Jerrold R Turner
Journal:  Lab Invest       Date:  2006-02       Impact factor: 5.662

4.  The role of an inwardly rectifying chloride conductance in postsynaptic inhibition.

Authors:  K Staley
Journal:  J Neurophysiol       Date:  1994-07       Impact factor: 2.714

5.  A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.

Authors:  Yevgeny Zolotarevsky; Gail Hecht; Athanasia Koutsouris; Deborah E Gonzalez; Cliff Quan; Jeffrey Tom; Randall J Mrsny; Jerrold R Turner
Journal:  Gastroenterology       Date:  2002-07       Impact factor: 22.682

6.  Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.

Authors:  Anselm A Zdebik; John E Cuffe; Marko Bertog; Christoph Korbmacher; Thomas J Jentsch
Journal:  J Biol Chem       Date:  2004-03-07       Impact factor: 5.157

7.  Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects.

Authors:  Seth Sweetser; Irene A Busciglio; Michael Camilleri; Adil E Bharucha; Lawrence A Szarka; Athanasios Papathanasopoulos; Duane D Burton; Deborah J Eckert; Alan R Zinsmeister
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-11-25       Impact factor: 4.052

Review 8.  Cell biology and physiology of CLC chloride channels and transporters.

Authors:  Tobias Stauber; Stefanie Weinert; Thomas J Jentsch
Journal:  Compr Physiol       Date:  2012-07       Impact factor: 9.090

9.  SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents.

Authors:  John Cuppoletti; Danuta H Malinowska; Kirti P Tewari; Qiu-Ju Li; Ann M Sherry; Myra L Patchen; Ryuji Ueno
Journal:  Am J Physiol Cell Physiol       Date:  2004-06-22       Impact factor: 4.249

10.  COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos.

Authors:  Y Chen; C Merzdorf; D L Paul; D A Goodenough
Journal:  J Cell Biol       Date:  1997-08-25       Impact factor: 10.539
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  6 in total

1.  Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus.

Authors:  Leandi Krüger; Tiffany A Pridgen; Ellie R Taylor; Katherine S Garman; Anthony T Blikslager
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2020-02-18       Impact factor: 4.052

2.  Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity.

Authors:  Younggeon Jin; Dina Ibrahim; Scott T Magness; Anthony T Blikslager
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-10-04       Impact factor: 4.052

Review 3.  The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases.

Authors:  Younggeon Jin; Anthony T Blikslager
Journal:  Int J Mol Sci       Date:  2020-05-18       Impact factor: 5.923

Review 4.  The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium.

Authors:  Zachary M Slifer; Anthony T Blikslager
Journal:  Int J Mol Sci       Date:  2020-02-01       Impact factor: 5.923

5.  The acidified drinking water-induced changes in the behavior and gut microbiota of wild-type mice depend on the acidification mode.

Authors:  Brandon Whipple; Jennifer Agar; Jing Zhao; David A Pearce; Attila D Kovács
Journal:  Sci Rep       Date:  2021-02-03       Impact factor: 4.379

6.  Chronic stress and intestinal permeability: Lubiprostone regulates glucocorticoid receptor-mediated changes in colon epithelial tight junction proteins, barrier function, and visceral pain in the rodent and human.

Authors:  Ye Zong; Shengtao Zhu; Shutian Zhang; Gen Zheng; John W Wiley; Shuangsong Hong
Journal:  Neurogastroenterol Motil       Date:  2018-10-04       Impact factor: 3.598
  6 in total

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