Yan-Ming Zhou1, Zhen-Yi Chen1, Xiu-Dong Li1, Dong-Hui Xu1, Xu Su1, Bin Li2. 1. Department of Hepatobiliary and Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, China. 2. Department of Hepatobiliary and Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, China. Binl1962@sina.cn.
Abstract
BACKGROUND AND AIM: Postoperative infection is not uncommon after hepatectomy. This study assessed the effectiveness of preoperative antibiotic prophylaxis in elective hepatectomy in a randomized clinical trial setting. METHODS: A total of 120 patients who were scheduled to undergo elective hepatectomy were equally randomized to receive either intravenous cefuroxime 1.5 g (group A) or placebo (group B) within 30 min prior to skin incision. RESULTS: Overall, postoperative infection occurred in 26 (21.6 %) of the 120 patients. There was no statistically significant difference between groups A and B in the incidence of overall infection (23.3 vs. 20.0 %, P = 0.658), surgical site infection (13.3 vs. 15 %, P = 0.793), and remote site infection (13.3 vs. 11.7 %, P = 0.783). CONCLUSION: The use of preoperative antibiotic prophylaxis as a routine practice in patients undergoing elective hepatectomy is unnecessary because it does not reduce the risk of postoperative infectious complications.
RCT Entities:
BACKGROUND AND AIM: Postoperative infection is not uncommon after hepatectomy. This study assessed the effectiveness of preoperative antibiotic prophylaxis in elective hepatectomy in a randomized clinical trial setting. METHODS: A total of 120 patients who were scheduled to undergo elective hepatectomy were equally randomized to receive either intravenous cefuroxime 1.5 g (group A) or placebo (group B) within 30 min prior to skin incision. RESULTS: Overall, postoperative infection occurred in 26 (21.6 %) of the 120 patients. There was no statistically significant difference between groups A and B in the incidence of overall infection (23.3 vs. 20.0 %, P = 0.658), surgical site infection (13.3 vs. 15 %, P = 0.793), and remote site infection (13.3 vs. 11.7 %, P = 0.783). CONCLUSION: The use of preoperative antibiotic prophylaxis as a routine practice in patients undergoing elective hepatectomy is unnecessary because it does not reduce the risk of postoperative infectious complications.
Entities:
Keywords:
Antibiotic prophylaxis; Hepatectomy; Infection; Surgical site infection
Authors: Nuh N Rahbari; Moritz Koch; Thomas Schmidt; Edith Motschall; Thomas Bruckner; Kathrin Weidmann; Arianeb Mehrabi; Markus W Büchler; Jürgen Weitz Journal: Ann Surg Oncol Date: 2009-01-07 Impact factor: 5.344
Authors: Nelson D Cabaluna; Gemma B Uy; Rommel M Galicia; Shalimar C Cortez; Marc Denver S Yray; Brian S Buckley Journal: World J Surg Date: 2013-01 Impact factor: 3.352