Literature DB >> 26715426

Histone deacetylase activity and recurrent bacterial bronchitis in severe eosinophilic asthma.

L Zuccaro1, A Cox1, C Pray1, K Radford1, K Novakowski2, M Dorrington2, M G Surette2,3, D Bowdish2, P Nair1.   

Abstract

An increase in P13 Kinase activity and an associated reduction in histone deacetylase activity may contribute to both relative steroid insensitivity in patients with severe eosinophilic asthma and impaired macrophage scavenger function and susceptibility to recurrent infective bronchitis that may, in turn, contribute to further steroid insensitivity.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  eosinophilic asthma; histone deacetylase; macrophage receptor with collagenous structure; sputum cell counts

Mesh：

Year:  2016        PMID： 26715426     DOI： 10.1111/all.12831

Source DB:  PubMed          Journal:  Allergy        ISSN： 0105-4538            Impact factor:   13.146


  4 in total

1.  Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.

Authors:  Manuel A R Ferreira; Riddhima Mathur; Judith M Vonk; Agnieszka Szwajda; Ben Brumpton; Raquel Granell; Bronwyn K Brew; Vilhelmina Ullemar; Yi Lu; Yunxuan Jiang; Patrik K E Magnusson; Robert Karlsson; David A Hinds; Lavinia Paternoster; Gerard H Koppelman; Catarina Almqvist
Journal:  Am J Hum Genet       Date:  2019-03-28       Impact factor: 11.025

2.  A prospective randomized controlled study: Theophylline on oxidative stress and steroid sensitivity in chronic obstructive pulmonary disease patients.

Authors:  R Ranjani; A T Sathiya Vinotha
Journal:  Int J Pharm Investig       Date:  2017 Jul-Sep

Review 3.  Post-tuberculous lung disease: should we be using Theophylline?

Authors:  Sumanth Karamchand; Morne Williams; Poobalan Naidoo; Eric Decloedt; Brian Allwood
Journal:  J Thorac Dis       Date:  2021-02       Impact factor: 2.895

Review 4.  Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma.

Authors:  Cristina Mihaela Ghiciuc; Andrei Gheorghe Vicovan; Celina Silvia Stafie; Sabina Antonela Antoniu; Paraschiva Postolache
Journal:  Mar Drugs       Date:  2021-10-20       Impact factor: 5.118
  4 in total

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