Yaou Liu1,2,3, Zhengjia Dai4,5, Yunyun Duan1, Jing Huang1, Zhuoqiong Ren1, Zheng Liu6, Huiqing Dong6, Ni Shu5, Hugo Vrenken2, Mike P Wattjes2, Frederik Barkhof2, Yong He7, Kuncheng Li8. 1. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of China. 2. Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, 1007 MB, The Netherlands. 3. Department of Neurology and Tianjin Neurological Institute, Tianjin Medical University, General Hospital, Tianjin, 300052, People's Republic of China. 4. Department of Psychology, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China. 5. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, People's Republic of China. 6. Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of China. 7. State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, 100875, People's Republic of China. yong.h.he@gmail.com. 8. Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, People's Republic of China. kunchengli55@gmail.com.
Abstract
OBJECTIVE: To investigate brain functional connectivity (FC) alterations in patients with clinically isolated syndromes (CIS) presenting without conventional brain MRI lesions, and to identify the FC differences between the CIS patients who converted to multiple sclerosis (MS) and those not converted during a 5-year follow-up. METHODS: We recruited 20 CIS patients without conventional brain lesions, 28 patients with MS and 28 healthy controls (HC). Normalized voxel-based functional connectivity strength (nFCS) was determined using resting-state fMRI (R-fMRI) and compared among groups. Furthermore, 5-years clinical follow-up of the CIS patients was performed to examine the differences in nFCS between converters and non-converters. RESULTS: Compared to HC, CIS patients showed significantly decreased nFCS in the visual areas and increased nFCS in several brain regions predominately in the temporal lobes. MS patients revealed more widespread higher nFCS especially in deep grey matter (DGM), compared to CIS and HC. In the four CIS patients converting to MS, significantly higher nFCS was found in right anterior cingulate gyrus (ACC) and fusiform gyrus (FG), compared to non-converted patients. CONCLUSION: We demonstrated both functional impairment and compensation in CIS by R-fMRI. nFCS alteration in ACC and FG seems to occur in CIS patients at risk of developing MS. KEY POINTS: • Both functional impairment and compensation occur in CIS without conventional brain lesions. • MS patients revealed more widespread higher nFCS especially in deep grey matter. • nFCS alteration may help stratifying CIS at risk of developing MS.
OBJECTIVE: To investigate brain functional connectivity (FC) alterations in patients with clinically isolated syndromes (CIS) presenting without conventional brain MRI lesions, and to identify the FC differences between the CIS patients who converted to multiple sclerosis (MS) and those not converted during a 5-year follow-up. METHODS: We recruited 20 CIS patients without conventional brain lesions, 28 patients with MS and 28 healthy controls (HC). Normalized voxel-based functional connectivity strength (nFCS) was determined using resting-state fMRI (R-fMRI) and compared among groups. Furthermore, 5-years clinical follow-up of the CIS patients was performed to examine the differences in nFCS between converters and non-converters. RESULTS: Compared to HC, CIS patients showed significantly decreased nFCS in the visual areas and increased nFCS in several brain regions predominately in the temporal lobes. MS patients revealed more widespread higher nFCS especially in deep grey matter (DGM), compared to CIS and HC. In the four CIS patients converting to MS, significantly higher nFCS was found in right anterior cingulate gyrus (ACC) and fusiform gyrus (FG), compared to non-converted patients. CONCLUSION: We demonstrated both functional impairment and compensation in CIS by R-fMRI. nFCS alteration in ACC and FG seems to occur in CIS patients at risk of developing MS. KEY POINTS: • Both functional impairment and compensation occur in CIS without conventional brain lesions. • MS patients revealed more widespread higher nFCS especially in deep grey matter. • nFCS alteration may help stratifying CIS at risk of developing MS.
Authors: Xi-Nian Zuo; Ross Ehmke; Maarten Mennes; Davide Imperati; F Xavier Castellanos; Olaf Sporns; Michael P Milham Journal: Cereb Cortex Date: 2011-10-02 Impact factor: 5.357
Authors: Alireza Minagar; Michael H Barnett; Ralph H B Benedict; Daniel Pelletier; Istvan Pirko; Mohamad Ali Sahraian; Elliott Frohman; Robert Zivadinov Journal: Neurology Date: 2013-01-08 Impact factor: 9.910
Authors: Chris H Polman; Stephen C Reingold; Brenda Banwell; Michel Clanet; Jeffrey A Cohen; Massimo Filippi; Kazuo Fujihara; Eva Havrdova; Michael Hutchinson; Ludwig Kappos; Fred D Lublin; Xavier Montalban; Paul O'Connor; Magnhild Sandberg-Wollheim; Alan J Thompson; Emmanuelle Waubant; Brian Weinshenker; Jerry S Wolinsky Journal: Ann Neurol Date: 2011-02 Impact factor: 10.422
Authors: Gloria Castellazzi; Laetitia Debernard; Tracy R Melzer; John C Dalrymple-Alford; Egidio D'Angelo; David H Miller; Claudia A M Gandini Wheeler-Kingshott; Deborah F Mason Journal: Front Neurol Date: 2018-08-20 Impact factor: 4.003
Authors: Marlene Tahedl; Seth M Levine; Mark W Greenlee; Robert Weissert; Jens V Schwarzbach Journal: Front Neurol Date: 2018-10-11 Impact factor: 4.003