Literature DB >> 26714924

Autoxidation/Aldol Tandem Reaction of 2-Oxindoles with Ketones: A Green Approach for the Synthesis of 3-Hydroxy-2-Oxindoles.

Qing-Bao Zhang1, Wen-Liang Jia1, Yong-Liang Ban1, Yong Zheng1, Qiang Liu2, Li-Zhu Wu3.   

Abstract

In the presence of tetrabutylammonium fluoride and molecular sieves (MS) 4 Å in DMF, an efficient autoxidation reaction of 2-oxindoles with ketones under air at room temperature has been developed. This approach may provide a green, practical, and metal-free protocol for a wide range of biologically important 3-hydroxy-3-(2-oxo-alkyl)-2-oxindoles.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Keywords:  C−H activation; autoxidation; oxindoles; oxygen; tetrabutylammonium fluoride

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Year:  2016        PMID: 26714924     DOI: 10.1002/chem.201504282

Source DB:  PubMed          Journal:  Chemistry        ISSN: 0947-6539            Impact factor:   5.236


  1 in total

1.  Electrochemical Umpolung C-H Functionalization of Oxindoles.

Authors:  Miryam Pastor; Marie Vayer; Harald Weinstabl; Nuno Maulide
Journal:  J Org Chem       Date:  2021-12-28       Impact factor: 4.354

  1 in total

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