Literature DB >> 26713213

Polymer optical fiber compound parabolic concentrator tip for enhanced coupling efficiency for fluorescence based glucose sensors.

Hafeez Ul Hassan1, Kristian Nielsen2, Soren Aasmul1, Ole Bang2.   

Abstract

We demonstrate that the light excitation and capturing efficiency of fluorescence based fiber-optical sensors can be significantly increased by using a CPC (Compound Parabolic Concentrator) tip instead of the standard plane-cut tip. We use Zemax modelling to find the optimum CPC tip profile and fiber length of a polymer optical fiber diabetes sensor for continuous monitoring of glucose levels. We experimentally verify the improved performance of the CPC tipped sensor and the predicted production tolerances. Due to physical size requirements when the sensor has to be inserted into the body a non-optimal fiber length of 35 mm is chosen. For this length an average improvement in efficiency of a factor of 1.7 is experimentally demonstrated and critically compared to the predicted ideal factor of 3 in terms of parameters that should be improved through production optimization.

Entities:  

Keywords:  (060.2370) Fiber optics sensors; (160.5470) Polymers; (170.1470) Blood or tissue constituent monitoring; (220.4298) Nonimaging optics

Year:  2015        PMID: 26713213      PMCID: PMC4679273          DOI: 10.1364/BOE.6.005008

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN: 2156-7085            Impact factor:   3.732


  14 in total

1.  Compound parabolic concentrator probe for efficient light collection in spectroscopy of biological tissue.

Authors:  K Tanaka; M T Pacheco; J F Brennan Iii; I Itzkan; A J Berger; R R Dasari; M S Feld
Journal:  Appl Opt       Date:  1996-02-01       Impact factor: 1.980

2.  Signal/noise analysis of FRET-based sensors.

Authors:  Andrew Woehler; Jakub Wlodarczyk; Erwin Neher
Journal:  Biophys J       Date:  2010-10-06       Impact factor: 4.033

3.  Compound parabolic tapered fiber for fiber coupling with a highly divergent source.

Authors:  Lee C Chen; Andy L Y Low; Su F Chien
Journal:  Appl Opt       Date:  2004-11-10       Impact factor: 1.980

Review 4.  Materials for fluorescence resonance energy transfer analysis: beyond traditional donor-acceptor combinations.

Authors:  Kim E Sapsford; Lorenzo Berti; Igor L Medintz
Journal:  Angew Chem Int Ed Engl       Date:  2006-07-10       Impact factor: 15.336

5.  Localized biosensing with Topas microstructured polymer optical fiber.

Authors:  Grigoriy Emiliyanov; Jesper B Jensen; Ole Bang; Poul E Hoiby; Lars H Pedersen; Erik M Kjaer; Lars Lindvold
Journal:  Opt Lett       Date:  2007-03-01       Impact factor: 3.776

6.  Fluorescence-based aluminum ion sensing using a surface-functionalized microstructured optical fiber.

Authors:  Stephen C Warren-Smith; Sabrina Heng; Heike Ebendorff-Heidepriem; Andrew D Abell; Tanya M Monro
Journal:  Langmuir       Date:  2011-04-06       Impact factor: 3.882

7.  A novel FRET-based optical fiber biosensor for rapid detection of Salmonella typhimurium.

Authors:  Sungho Ko; Sheila A Grant
Journal:  Biosens Bioelectron       Date:  2005-07-22       Impact factor: 10.618

8.  Selective detection of antibodies in microstructured polymer optical fibers.

Authors:  Jesper Jensen; Poul Hoiby; Grigoriy Emiliyanov; Ole Bang; Lars Pedersen; Anders Bjarklev
Journal:  Opt Express       Date:  2005-07-25       Impact factor: 3.894

9.  Clinical evaluation of a transcutaneous interrogated fluorescence lifetime-based microsensor for continuous glucose reading.

Authors:  Jannik K Nielsen; Jens S Christiansen; Jesper S Kristensen; Hans O Toft; Lars Lundby Hansen; Søren Aasmul; Klaus Gregorius
Journal:  J Diabetes Sci Technol       Date:  2009-01

10.  Percutaneous fiber-optic sensor for chronic glucose monitoring in vivo.

Authors:  Kuo-Chih Liao; Thieo Hogen-Esch; Frances J Richmond; Laura Marcu; William Clifton; Gerald E Loeb
Journal:  Biosens Bioelectron       Date:  2008-01-18       Impact factor: 10.618

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