| Literature DB >> 26712613 |
Supichar Chokpaiboon1, Siwattra Choodej2, Nattawut Boonyuen3, Thapong Teerawatananond4, Khanitha Pudhom5.
Abstract
Five highly oxygenated chromones, rhytidchromones A-E, were isolated from the culture broth of a mangrove-derived endophytic fungus, Rhytidhysteron rufulum, isolated from Thai Bruguiera gymnorrhiza. Their structures were determined by analysis of 1D and 2D NMR spectroscopic data. The structure of rhytidchromone A was further confirmed by single-crystal X-ray diffraction analysis. These compounds were evaluated for cytotoxicity against four cancer cell lines (MCF-7, Hep-G2, Kato-3 and CaSki). All compounds, except for rhytidchromone D, displayed cytotoxicity against Kato-3 cell lines with IC50 values ranging from 16.0 to 23.3μM, while rhytidchromones A and C were active against MCF-7 cells with IC50 values of 19.3 and 17.7μM, respectively.Entities:
Keywords: Chromone; Cytotoxicity; Endophytic fungi; Rhytidhysteron rufulum
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Year: 2015 PMID： 26712613 DOI： 10.1016/j.phytochem.2015.12.010
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072